Repository of Research and Investigative Information

Repository of Research and Investigative Information

Baqiyatallah University of Medical Sciences

Investigations of renal function using the level of neutrophil gelatinase-associated lipocalin associated with single-dose of cisplatin during chemotherapy

(2015) Investigations of renal function using the level of neutrophil gelatinase-associated lipocalin associated with single-dose of cisplatin during chemotherapy. Diagnostic Pathology. ISSN 17461596 (ISSN)

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Official URL: https://www.scopus.com/inward/record.uri?eid=2-s2....

Abstract

Background: Neutrophil gelatinase-associated lipocalin (NGAL) is known as a primary indicator of acute and chronic renal and can be effective in chronic kidney injury (CKI) with kidney tumors cisplatin (CP) chemotherapy. The aim of this study was to evaluate serum and urinary biomarker including NGAL (sNGAL and uNGAL) in canine with solid renal tumors who suffered from cisplatin after short and long-term chemotherapy. Methods: In this study, in treatment and control groups, canine (n = 10 and n = 5) were administered cisplatin at 1.2 mg/kg/day (i.v.) for five consecutive days with CKI and without CKI, respectively. Serum and urine NGAL levels (ng/mL) were evaluated at 0, 1, 5, 9, 13, 17, 21, 25 and 29 days after drug injection versus baseline in treated and control groups. Results: Canine in treatment group had shown symptoms of toxicity of cisplatin. The results indicated the higher concentrations of serum, sNGAL and uNGAL (P = 0.024; P = 0.011) compared with control group (P = 0.701, P = 0.612), (Table 2, Figs. 1 and 2). Indeed, our results showed that canine with CKI were associated with higher levels of sNGAL and uNGAL compared with control group without CKI. Moreover, the highest level of uNGAL was seen in comparison with sNGAL, after a high dose (1.2 mg/kg) administration of CP. Conclusion: Our data suggested that U-NGAL may be useful for monitoring of renal injury in CKI patients that exposed with cisplatin. Furthermore, a primary elevate in urinary NGAL expulsion may help in identifying cases at danger of cisplatin-induced CKI that might profit from innovative remedies to prevent cisplatin nephrotoxicity. © 2015 Maghsoudi et al.

Item Type: Article
Keywords: Cisplatin Kidney Marker Pathology Tumor acute phase protein antineoplastic agent biological marker lipocalin neutrophil gelatinase-associated lipocalin protein, dog oncoprotein Acute Kidney Injury animal blood chemically induced complication disease model dog drug administration drug effects drug monitoring intravenous drug administration kidney function test Kidney Neoplasms male metabolism pathophysiology predictive value procedures Renal Insufficiency, Chronic retracted article risk factor treatment outcome urine Acute-Phase Proteins Administration, Intravenous Animals Antineoplastic Agents Biomarkers Disease Models, Animal Dogs Drug Administration Schedule Kidney Function Tests Lipocalins Predictive Value of Tests Proto-Oncogene Proteins Risk Factors
Divisions:
Journal or Publication Title: Diagnostic Pathology
Journal Index: Scopus
Volume: 10
Number: 1
Identification Number: https://doi.org/10.1186/s13000-015-0338-5
ISSN: 17461596 (ISSN)
Depositing User: مهندس مهدی شریفی
URI: http://eprints.bmsu.ac.ir/id/eprint/385

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