Abstract

Trabectedin is one of the most important marine alkaloids derived from Ecteinascidia turbinate. It is used as anticancer agent, especially for ovarian cancer treatment. Nowadays, it is recommended as a combination therapy in patients with platinum - sensitive and/or platinum-resistant ovarian cancer. Some clinical studies showed that trabectedin has beneficial effect s against the progression of platinum-sensitive advanced or recurrent ovarian cancer in women. In view of its manageable tolerability profile, it can be recommended as a standard anticancer drug for patients who suffer from platinum -sensitive and/or -resistant ovarian cancer. In this chapter we critically reviewed the anticancer effects of trabectedin against platinum-sensitive and/or -resistant ovarian cancer so far described in literature. Furthermore, we will provide information about chemistry, molecular mechanisms and the recommended doses of trabectedin required to achieve the anticancer effects. © 2015 by Nova Science Publishers, Inc. All rights reserved.