(2018) SeFv Improvement Approaches. Protein and Peptide Letters. pp. 222-229. ISSN 0929-8665
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Abstract
The most common recombinant antibody format is the single chain fragment variable (scFv) which it contains the complete antigen-binding domains of an intact antibody. ScFv fragments have found vast medical and non-medical applications. Several approaches have been employed to increase the affinity, avidity and structural stability related to these antibody fragments. Most approaches related to scFv improvement have been included in this review.
| Item Type: | Article |
|---|---|
| Keywords: | scFv avidity affinity scFv stability recombinant antibody antibody fragments single-chain-fv complementarity-determining regions affinity maturation antibody fragments recombinant immunotoxins molecular evolution variable fragment scfv antibodies disulfide bonds phage display Biochemistry & Molecular Biology |
| Divisions: | |
| Page Range: | pp. 222-229 |
| Journal or Publication Title: | Protein and Peptide Letters |
| Journal Index: | ISI |
| Volume: | 25 |
| Number: | 3 |
| Identification Number: | https://doi.org/10.2174/0929866525666171129225436 |
| ISSN: | 0929-8665 |
| Depositing User: | مهندس مهدی شریفی |
| URI: | http://eprints.bmsu.ac.ir/id/eprint/4025 |
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