(2018) Vibrio cholerae lipopolysaccharide loaded chitosan nanoparticle could save life by induction of specific immunoglobulin isotype. Artificial Cells Nanomedicine and Biotechnology. pp. 56-61. ISSN 2169-1401
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Vibrio cholerae lipopolysaccharide loaded chitosan nanoparticle could save life by induction of specific immunoglobulin isotype.pdf Download (1MB) |
Abstract
The lipopolysaccharide (LPS) of Vibrio cholerae (V. cholerae) plays an important role in cholera disease and the induction of primary protection. In this study, we evaluate mice humoral immune response in intranasal and intraperitoneal administrated V. cholerae LPS. The results showed that the intranasal administration of LPS-chitosan nanoparticle induced the high level of antibodies compared to intraperitoneal injection of antigen without chitosan (P<.001). These results indicated that intranasal and intraperitoneal administration of LPS has been able to induce the high level of antibodies both in the sera and lavage fluid and confirmed our strategy for using intranasal administration of antigen.
| Item Type: | Article |
|---|---|
| Keywords: | Antibody chitosan LPS nanoparticle vaccine Vibrio cholerae o-specific polysaccharide intranasal vaccine escherichia-coli immune-responses cell responses infection delivery immunogenicity brucella antigen Biotechnology & Applied Microbiology Engineering Materials Science |
| Divisions: | |
| Page Range: | pp. 56-61 |
| Journal or Publication Title: | Artificial Cells Nanomedicine and Biotechnology |
| Journal Index: | ISI |
| Volume: | 46 |
| Number: | 1 |
| Identification Number: | https://doi.org/10.1080/21691401.2017.1290646 |
| ISSN: | 2169-1401 |
| Depositing User: | مهندس مهدی شریفی |
| URI: | http://eprints.bmsu.ac.ir/id/eprint/4041 |
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