Repository of Research and Investigative Information

Repository of Research and Investigative Information

Baqiyatallah University of Medical Sciences

An electrochemical sensor for the simultaneous determination of rifampicin and isoniazid using a C-dots@CuFe2O4 nanocomposite modified carbon paste electrode

(2017) An electrochemical sensor for the simultaneous determination of rifampicin and isoniazid using a C-dots@CuFe2O4 nanocomposite modified carbon paste electrode. New Journal of Chemistry. pp. 15564-15573. ISSN 1144-0546

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Abstract

In this study, a sensitive carbon paste electrode based on a novel nanocomposite of carbon dots/CuFe2O4 (C-dots@CuFe2O4) was developed for the simultaneous determination of rifampicin (RIF) and isoniazid (INZ). The morphological and structural properties of the C-dots@CuFe2O4 were well characterized by transmission electron microscopy (TEM), Fourier transform infrared spectroscopy (FTIR) and X-ray diffraction (XRD). Under the optimized conditions, the voltammetric current increased linearly on increasing the concentration of RIF and INZ in the range of 0.07 to 8.0 and 0.1 to 14.0 mu mol L-1, respectively. Moreover, the detection limits for the analytes were calculated to be 0.022 mu mol L-1 for RIF and 0.041 mu mol L-1 for INZ based on 3S(b)/m. The practical applicability of the proposed sensor was examined by evaluating the detection of RIF and INZ in biological fluids and pharmaceutical samples with satisfactory recoveries. The C-dots@CuFe2O4/CPE can hold great promise for fast, simple and sensitive detection of RIF and INZ in various real samples.

Item Type: Article
Keywords: reduced graphene oxide performance liquid-chromatography pharmaceutical formulations mnfe2o4 nanoparticles magnetic-properties human serum pyrazinamide plasma biosensor drugs Chemistry
Divisions:
Page Range: pp. 15564-15573
Journal or Publication Title: New Journal of Chemistry
Journal Index: ISI
Volume: 41
Number: 24
Identification Number: https://doi.org/10.1039/c7nj03029k
ISSN: 1144-0546
Depositing User: مهندس مهدی شریفی
URI: http://eprints.bmsu.ac.ir/id/eprint/4072

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