(2017) The functional significance of 14-3-3 proteins in cancer: focus on lung cancer. Hormone Molecular Biology and Clinical Investigation. p. 17. ISSN 1868-1883
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Abstract
The 14-3-3 family proteins are phosphoserine/phosphothreonine binding proteins constituting a conserved class of proteins which are detected in all eukaryotic cells. In mammalians, 14-3-3 proteins have seven distinct isoforms (beta, gamma, epsilon, eta, zeta, sigma and tau/theta) which are involved in various cellular processes including signal transduction, cell cycle, cell proliferation, apoptosis, differentiation and survival. 14-3-3 proteins do not have a distinct catalytic activity and often regulate the activity, stability, subcellular localization and interactions of other proteins. The 14-3-3 family proteins function through interacting with their client proteins or facilitating the interaction of other proteins likely as adaptor proteins. The versatile functions of these proteins in the regulation of cell growth, cell division, cell death and cell migration make them candidate proteins for which an important role in cancer development could be envisioned. Indeed, analysis of cancer cell lines and tumor-derived tissues have indicated the differential abundance or post-translational modification of some 14-3-3 isoforms. In this review, we aimed to show how deregulation of 14-3-3 proteins contributes to initiation, establishment and progression of cancers with a particular emphasis on lung cancer. The role of these proteins in cancer-relevant processes including cell cycle, cell migration, cell-cell communication and programmed cell death will be discussed in detail.
Item Type: | Article |
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Keywords: | cancer cell cycle cell proliferation lung cancer protein interaction 14-3-3 proteins cofilin-phosphatase slingshot foxo transcription factors cell-cycle breast-cancer dna-damage tumor-suppressor down-regulation molecular-mechanisms kinase phosphorylation Biochemistry & Molecular Biology |
Divisions: | |
Page Range: | p. 17 |
Journal or Publication Title: | Hormone Molecular Biology and Clinical Investigation |
Journal Index: | ISI |
Volume: | 32 |
Number: | 3 |
Identification Number: | https://doi.org/10.1515/hmbci-2017-0032 |
ISSN: | 1868-1883 |
Depositing User: | مهندس مهدی شریفی |
URI: | http://eprints.bmsu.ac.ir/id/eprint/4108 |
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