Repository of Research and Investigative Information

Repository of Research and Investigative Information

Baqiyatallah University of Medical Sciences

The effect of chrysin-loaded nanofiber on wound healing process in male rat

(2017) The effect of chrysin-loaded nanofiber on wound healing process in male rat. Chemical Biology & Drug Design. pp. 1106-1114. ISSN 1747-0277

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Abstract

Wound healing is an inflammatory process. Chrysin, a natural flavonoid found in honey, has been recently investigated to have anti-inflammatory and antioxidant effects. In this work, the effects of chrysin-loaded nanofiber on the expressions of genes that are related to wound healing process such as P53, TIMPs, MMPs, iNOS, and IL-6 in an animal model study were evaluated. The electrospinning method was used for preparation the different concentrations of chrysin-loaded PCL-PEG nanofiber (5, 10, and 20 w/w) and characterized by FTIR and SEM. The wound healing effects of chrysin-loaded PCL-PEG nanofiber were in vivo investigated in rats, and the expressions of genes related to wound healing process were evaluated by real-time PCR. The study results showed chrysin-loaded PLC-PEG compared to chrysin ointment and control groups significantly increase IL-6, MMP-2, MMP-8, MMP-9, TIMP-1, and TIMP-2 (p<.05). On the other hand, nanofibers containing chrysin significantly decreased p53 and iNOS expression compared to chrysin ointment and control groups (p<.05). According to the results, chrysin-loaded PCL-PEG-PCL nanofibers have positive effects on the expression of the genes that have pivotal role in wound healing.

Item Type: Article
Keywords: chrysin chrysin-loaded PCL-PEG-PCL nanofiber gene expression open wound healing Biochemistry & Molecular Biology Pharmacology & Pharmacy
Divisions:
Page Range: pp. 1106-1114
Journal or Publication Title: Chemical Biology & Drug Design
Journal Index: ISI
Volume: 90
Number: 6
Identification Number: https://doi.org/10.1111/cbdd.12996
ISSN: 1747-0277
Depositing User: مهندس مهدی شریفی
URI: http://eprints.bmsu.ac.ir/id/eprint/4116

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