Repository of Research and Investigative Information

Repository of Research and Investigative Information

Baqiyatallah University of Medical Sciences

Nutrigenomics in cancer: Revisiting the effects of natural compounds

(2017) Nutrigenomics in cancer: Revisiting the effects of natural compounds. Seminars in Cancer Biology. pp. 84-106. ISSN 1044-579X

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Nutrigenomics effects have an important role in the manipulation of dietary components for human benefit, particularly in cancer prevention or treatment. The impact of dietary components, including phytochemicals, is largely studied by nutrigenomics, looking at the gene expression and molecular mechanisms interacting with bioactive compounds and nutrients, based on new 'omics' technologies. The high number of preclinical studies proves the relevant role of nutrigenomics in cancer management. By deciphering the network of nutrient-gene connections associated with cancer, relevant data will be transposed as therapeutic interventions for this devastating pathology and for fulfilling the concept of personalized nutrition. All these are presented under the nutrigenomics canopy for a better comprehension of the relation between ingested phytochemicals and chemoprevention or chemotherapy. The profits from the nutrigenomics progress, with a particular focus on the coding and noncoding genes related to the exposure of natural compounds need to be validated. A precise attention receives the evaluation of the role of natural compounds in tandem with conventional therapy using genomic approaches, with emphasis on the capacity to inhibit drug resistance mechanisms. All these relevant nutrigenomics aspects are summarized in the present review paper. It is concluded that further nutrigenomics studies are required to improve our understanding related to the complex mechanisms of action of the natural compounds and for their appropriate application as gears in cancer therapy.

Item Type: Article
Keywords: Nutrigenomics Natural compounds Cancer green tea polyphenol tumor-suppressor genes to-mesenchymal transition breast-cancer prostate-cancer lung-cancer cell-death in-vitro signaling pathways carcinoma-cells Oncology
Page Range: pp. 84-106
Journal or Publication Title: Seminars in Cancer Biology
Journal Index: ISI
Volume: 46
Identification Number:
ISSN: 1044-579X
Depositing User: مهندس مهدی شریفی

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