(2017) In vitro proliferation and differentiation of human bone marrow mesenchymal stem cells into osteoblasts on nanocomposite scaffolds based on bioactive glass (64SiO(2)-31CaO-5P(2)O(5))-poly-L-lactic acid nanofibers fabricated by electrospinning method. Materials Science & Engineering C-Materials for Biological Applications. pp. 114-123. ISSN 0928-4931
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Abstract
Electrospinning method was employed for fabrication of SiO2-CaO-P2O5 bioactive glass (BG) nanofibers, poly-L-lactic acid (PLLA) nanofibers and nanocomposite scaffolds fabricated from as-prepared nanofibers. Characterization of the prepared nanofibers and scaffolds by XRD, FTIR, and SEM techniques revealed the formation of nano fibers with mean diameter of about 500 nm and fully fibrous scaffolds with porous structure and interconnected pores. The growth, viability and proliferation of cultured human bone marrow mesenchymal stem cells in the fabricated nanofibers and bioactive glass-poly-L-lactic acid (BG-PLLA) nanocomposite scaffolds were studied using various biological assays including MTT, ALP activity, calcium deposit content, Alizarin red staining, and RT-PCR test. Based on the obtained results, incorporation of BG nanofibers in the nanocomposite scaffolds causes the better biological behavior of the scaffolds. In addition, three-dimensional and fibrous-porous structure of the scaffolds further contributes to their improved cell behavior compared to the components. (C) 2017 Elsevier B.V. All rights reserved.
| Item Type: | Article |
|---|---|
| Keywords: | Bioactive glass PLLA Nanofiber Nanocomposite scaffold In-vitro behavior sol-gel synthesis biomedical applications mechanical-properties nanoparticles hydroxyapatite particles behavior matrix size Materials Science |
| Divisions: | |
| Page Range: | pp. 114-123 |
| Journal or Publication Title: | Materials Science & Engineering C-Materials for Biological Applications |
| Journal Index: | ISI |
| Volume: | 78 |
| Identification Number: | https://doi.org/10.1016/j.msec.2017.02.165 |
| ISSN: | 0928-4931 |
| Depositing User: | مهندس مهدی شریفی |
| URI: | http://eprints.bmsu.ac.ir/id/eprint/4288 |
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