Repository of Research and Investigative Information

Repository of Research and Investigative Information

Baqiyatallah University of Medical Sciences

Preparation and evaluation of polyurethane/cellulose nanowhisker bimodal foam nanocomposites for osteogenic differentiation of hMSCs

(2017) Preparation and evaluation of polyurethane/cellulose nanowhisker bimodal foam nanocomposites for osteogenic differentiation of hMSCs. Carbohydrate Polymers. pp. 281-291. ISSN 0144-8617

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Abstract

Biocompatible and biodegradable polyurethanes (PUs) based on polycaprolactone diol (PCL) were prepared and filled with cellulose nanowhiskers (CNWs) obtained from wastepaper. The incorporated polyurethane nanocomposites were used to prepare foamed scaffolds with bimodal cell sizes through solvent casting/particulate leaching method. Sodium chloride and sugar porogens were also prepared to fabricate the scaffolds. The mechanical and thermal properties of PU/CNW nanocomposites were investigated. Incorporation of different CNWs resulted in various structures with tunable mechanical properties and biodegradability. All bimodal foam nanocomposites were biodegradable and also non-cytotoxic as revealed by MIT assay using SNL fibroblast cell line. PU/CNW foam scaffolds were used for osteogenic differentiation of human mesenchymal stem cells (hMSCs). Based on the results, such PU/CNW nanocomposites could support proliferation and osteogenic differentiation of hMSCs in three-dimensional synthetic extracellular matrix (ECM). (C) 2017 Elsevier Ltd. All rights reserved.

Item Type: Article
Keywords: Polyurethane (PU) Cellulose nanowhisker (CNW) Human mesenchymal stem cell (hMSC) Osteogenic differentiation Bimodal foam scaffold mesenchymal stem-cells biomedical applications bone tissue composite scaffolds castor-oil cellulose fabrication elastomer modulus peg Chemistry Polymer Science
Divisions:
Page Range: pp. 281-291
Journal or Publication Title: Carbohydrate Polymers
Journal Index: ISI
Volume: 171
Identification Number: https://doi.org/10.1016/j.carbpol.2017.05.027
ISSN: 0144-8617
Depositing User: مهندس مهدی شریفی
URI: http://eprints.bmsu.ac.ir/id/eprint/4291

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