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Repository of Research and Investigative Information

Baqiyatallah University of Medical Sciences

Effects of intra-amygdala memantine infusion on metabolic symptoms induced by chronic stress in male NMRI mice

(2015) Effects of intra-amygdala memantine infusion on metabolic symptoms induced by chronic stress in male NMRI mice. Koomesh. pp. 376-383. ISSN 16087046 (ISSN)

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Abstract

Introduction: Pervious studies indicate an important role for amygdala in stress. In addition, glutamate inputs to the amygdala are activated during stress. In the present study, the effects of amygdala NMDA glutamate receptors inhibition on metabolic symptoms induced by chronic stress in male NMRI mice were investigated. Material and Methods: Intra-amygdala uni- or bi-lateral cannulations were performed. Seven days after recovery from surgery animals received different doses of memantine (0.1, 0.5 and 1 µg/mouse) five minutes before inducing stress. Stress was applied for seven consecutive days. Changes in the amount of food and water intake and delay in eating and defecation were considered as indicators for stress. Results: Stress reduced food, while increased water intake and delayed the time of eating and defecation. Intra-amygdala memantine injections exacerbated the effects of stress on food intake except with the medium and high doses in the right side of the nucleus. Memantine also inhibited the effects of stress on water intake except with the medium doses in the right side. Also, reduced delay in the time of eating significantly. On the other hand, memantine inhibited or increased effects of stress on defecation, in a dose- and side- dependent manner. Conclusion: Stress activates glutamatergic systems in the amygdala and impacts the metabolic functions. This effect is probably based on the concentration and the side of neurotransmitter action in the nucleus. © 2015, Semnan University of Medical Sciences. All rights reserved.

Item Type: Article
Keywords: Amygdala Memantine N-Methyl-D-Aspartate receptors Stress n methyl dextro aspartic acid receptor amygdaloid nucleus animal experiment animal model Article cannulation chronic stress defecation eating fluid intake food intake male metabolic disorder mouse nonhuman
Divisions:
Page Range: pp. 376-383
Journal or Publication Title: Koomesh
Journal Index: Scopus
Volume: 16
Number: 3
ISSN: 16087046 (ISSN)
Depositing User: مهندس مهدی شریفی
URI: http://eprints.bmsu.ac.ir/id/eprint/443

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