Repository of Research and Investigative Information

Repository of Research and Investigative Information

Baqiyatallah University of Medical Sciences

A focus on resveratrol and ocular problems, especially cataract: From chemistry to medical uses and clinical relevance

(2017) A focus on resveratrol and ocular problems, especially cataract: From chemistry to medical uses and clinical relevance. Biomedicine & Pharmacotherapy. pp. 232-241. ISSN 0753-3322

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Low vision and blindness are important health problems that affect millions of people throughout the world. The most common and important pathologies are diabetic retinopathy, age-related macular degeneration, glaucoma as well as cataracts. The latter consists of an opacification of the lens of the eye which impedes the passage of light and represents one of the most important causes of vision loss. Among the risk factors for cataract development, there are life-style factors such as the use of tobacco, abuse of alcohol and unhealthy diet. In light of this, dietary components that possess anti-oxidant activity, such as polyphenols for instance, can be considered good candidates for human studies in the prevention and or treatment of such diseases. Among dietary components, the antioxidant capacity of certain polyphenols is well known, and these could be good candidates. In this review we focus our attention on the current scientific literature regarding to the effects of resveratrol on cataracts and other ocular diseases, along with its potential mechanism/s of action. A large number of preclinical studies support the involvement of resveratrol in clinical trials for the prevention and treatment of eye diseases induced by oxidative stress and inflammation, such as age-related cataract. (C) 2016 Elsevier Masson SAS. All rights reserved.

Item Type: Article
Keywords: Cataracts Resveratrol Ocular diseases Phytochemicals induced oxidative stress natural-product present lens epithelial-cells trans-resveratrol cis-resveratrol human liver poly(adp-ribose) polymerase antioxidant properties induced-apoptosis ortho-tyrosine Research & Experimental Medicine Pharmacology & Pharmacy
Page Range: pp. 232-241
Journal or Publication Title: Biomedicine & Pharmacotherapy
Journal Index: ISI
Volume: 86
Identification Number:
ISSN: 0753-3322
Depositing User: مهندس مهدی شریفی

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