Repository of Research and Investigative Information

Repository of Research and Investigative Information

Baqiyatallah University of Medical Sciences

Nanomolar simultaneous determination of tryptophan and melatonin by a new ionic liquid carbon paste electrode modified with SnO2-Co3O4@rGO nanocomposite

(2017) Nanomolar simultaneous determination of tryptophan and melatonin by a new ionic liquid carbon paste electrode modified with SnO2-Co3O4@rGO nanocomposite. Materials Science & Engineering C-Materials for Biological Applications. pp. 386-394. ISSN 0928-4931

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Abstract

This work describes the development of a new sensor for simultaneous determination of tryptophan and melatonin. The proposed sensor was an ionic liquid carbon paste electrode modified with reduced graphene oxides decorated with SnO2-Co3O4 nanoparticles. The voltammetric oxidation of the analytes by the proposed sensor confirmed that the electrooxidation process undergoes a two-electron/one-proton reaction for melatonin and a two-electron/two-proton reaction for tryptophan in diffusion-controlled processes. Moreover, based on the excellent electrochemical properties of the modified electrode, a sensitive voltammetric method was used for individual and simultaneous determination of melatonin and tryptophan in the aqueous solutions. Under the optimized experimental conditions, a linear response obtained in the range of 0.02 to 6.00 mu mol L-1 with detection limits of 4.1 and 32 nmol L-1 for melatonin and tryptophan, respectively. The prepared sensor possessed accurate and rapid response toward melatonin and tryptophan with a good sensitivity, selectivity, stability, and repeatability. Finally, the applicability of the proposed sensor was verified by evaluation of melatonin and tryptophan in various real samples including human serum and tablet samples. (C) 2016 Elsevier B.V. All rights reserved.

Item Type: Article
Keywords: Electrochemical sensors Simultaneous determination Tryptophan Melatonin SnO2-Co3O4@rGO nanocomposite Modified electrode reduced graphene oxide simultaneous electrochemical determination uric-acid sensitive determination facile synthesis ascorbic-acid in-situ nanoparticles sensor reduction Materials Science
Divisions:
Page Range: pp. 386-394
Journal or Publication Title: Materials Science & Engineering C-Materials for Biological Applications
Journal Index: ISI
Volume: 71
Identification Number: https://doi.org/10.1016/j.msec.2016.10.020
ISSN: 0928-4931
Depositing User: مهندس مهدی شریفی
URI: http://eprints.bmsu.ac.ir/id/eprint/4582

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