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Repository of Research and Investigative Information

Baqiyatallah University of Medical Sciences

Therapeutic role of sirtuins in neurodegenerative disease and their modulation by polyphenols

(2017) Therapeutic role of sirtuins in neurodegenerative disease and their modulation by polyphenols. Neuroscience and Biobehavioral Reviews. pp. 39-47. ISSN 0149-7634

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Abstract

Searching for effective therapeutic agents to prevent neurodegeneration is a challenging task due to the growing list of neurodegenerative disorders associated with a multitude of inter-related pathways. The induction and inhibition of several different signaling pathways has been shown to slow down and/or attenuate neurodegeneration and decline in cognition and locomotor function. Among these signaling pathways, a new class of enzymes known as sirtuins or silent information regulators of gene transcription has been shown to play important regulatory roles in the ageing process. SIRT1, a nuclear sirtuin, has received particular interest due to its role as a deacetylase for several metabolic and signaling proteins involved in stress response, apoptosis, mitochondrial function, self-renewal, and neuroprotection. A new strategy to treat neurodegenerative diseases is targeted therapy. In this paper, we reviewed up-to-date findings regarding the targeting of SIRT1 by polyphenolic compounds, as a new approach in the search for novel, safe and effective treatments for neurodegenerative diseases. (C) 2016 Elsevier Ltd. All rights reserved.

Item Type: Article
Keywords: Ageing Neurodegeneration Polyphenolic SIRT1 Sirtuins unfolded protein response primary cultured rat blood-brain-barrier nf-kappa-b mitochondrial dysfunction oxidative stress gene-expression endoplasmic-reticulum epigenetic regulation induced neurotoxicity Behavioral Sciences Neurosciences & Neurology
Divisions:
Page Range: pp. 39-47
Journal or Publication Title: Neuroscience and Biobehavioral Reviews
Journal Index: ISI
Volume: 73
Identification Number: https://doi.org/10.1016/j.neubiorev.2016.11.022
ISSN: 0149-7634
Depositing User: مهندس مهدی شریفی
URI: http://eprints.bmsu.ac.ir/id/eprint/4584

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