Repository of Research and Investigative Information

Repository of Research and Investigative Information

Baqiyatallah University of Medical Sciences

Immunotoxin: A new tool for cancer therapy

(2017) Immunotoxin: A new tool for cancer therapy. Tumor Biology. p. 11. ISSN 1010-4283

[img] Text
Immunotoxin A new tool for cancer therapy.pdf

Download (312kB)

Official URL: http://apps.webofknowledge.com/InboundService.do?F...

Abstract

Cancer is one of the main reasons of death in the most countries and in Iran. Immunotherapy quickly became one of the best methods of cancer treatment, along with chemotherapy and radiation. "Immunotoxin Therapy" is a promising way of cancer therapy that is mentioned in this field. Immunotoxins are made from a toxin attaching to an antibody target proteins present on cancer cells. The first-generation immunotoxins were made of a full-length toxin attached to whole monoclonal antibodies. But, these immunotoxins could bind to normal cells. DAB389IL2 was the first immunotoxin approved by the Food and Drug Administration. Current trends and researches are ongoing on finding proteins that in combination with immunotoxins have minimal immunogenicity and the most potency for target cell killing.

Item Type: Article
Keywords: Toxins antibody immunotoxins cancer therapy acute myeloid-leukemia b-cell epitopes acute lymphoblastic-leukemia ribosome-inactivating proteins chronic lymphocytic-leukemia colony-stimulating factor phase-i trial fusion protein recombinant immunotoxin diphtheria-toxin Oncology
Divisions:
Page Range: p. 11
Journal or Publication Title: Tumor Biology
Journal Index: ISI
Volume: 39
Number: 2
Identification Number: https://doi.org/10.1177/1010428317692226
ISSN: 1010-4283
Depositing User: مهندس مهدی شریفی
URI: http://eprints.bmsu.ac.ir/id/eprint/4587

Actions (login required)

View Item View Item