Repository of Research and Investigative Information

Repository of Research and Investigative Information

Baqiyatallah University of Medical Sciences

Investigation of anticarcinogenic and antioxidant effects of 4-methylimidazole

(2017) Investigation of anticarcinogenic and antioxidant effects of 4-methylimidazole. Bratislava Medical Journal-Bratislavske Lekarske Listy. pp. 149-152. ISSN 0006-9248

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Abstract

4-methylimidazole is widely used in pharmaceuticals, photographic and agricultural chemicals. The substance is extensively found in many human and animals foods. In this research, anticancer effect of the 4-MEI was studded using MIT test using MCF-7 cell line. Effect of the 4-MEI on apoptosis or necrosis was analyzed by DNA fragmentation assay using Swiss Albino rats as a model organism. Antioxidant effect of the substance was investigated by assaying protective effect of the substance on circular plasmid DNA against H2O2 as an oxidative agent. 4-MEI showed inhibitory effect on proliferation of MCF-7 cell line by all concentrations and the decrement was significant and concentration dependent. Result of DNA fragmentation assay showed 4-MEI concentrations dependent of smear formation showing necrotic effects of the 4-MEI on mouse cells. Also, the 4-MEI showed a good antioxidant activity and protective effect against H2O2. CONCLUSION: The result of this study showed that 4MEI has significant antioxidant and anti-cancer effect. Also, according to the result, 4-MEI has necrotic effects on mouse cells (Fig. 3, Ref. 21). Text in PDF www.elis.sk.

Item Type: Article
Keywords: 4-MEI MCF-7 fragmentation antioxidant anticancer caramel color carcinogenicity toxicity rats General & Internal Medicine
Divisions:
Page Range: pp. 149-152
Journal or Publication Title: Bratislava Medical Journal-Bratislavske Lekarske Listy
Journal Index: ISI
Volume: 118
Number: 3
Identification Number: https://doi.org/10.4149/bll₂₀₁₇₀₂₉
ISSN: 0006-9248
Depositing User: مهندس مهدی شریفی
URI: http://eprints.bmsu.ac.ir/id/eprint/4711

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