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Repository of Research and Investigative Information

Baqiyatallah University of Medical Sciences

Phytochemicals for human disease: An update on plant-derived compounds antibacterial activity

(2017) Phytochemicals for human disease: An update on plant-derived compounds antibacterial activity. Microbiological Research. pp. 44-68. ISSN 0944-5013

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Abstract

In recent years, many studies have shown that phytochemicals exert their antibacterial activity through different mechanisms of action, such as damage to the bacterial membrane and suppression of virulence factors, including inhibition of the activity of enzymes and toxins, and bacterial biofilm formation. In this review, we summarise data from the available literature regarding the antibacterial effects of the main phytochemicals belonging to different chemical classes, alkaloids, sulfur-containing phytochemicals, terpenoids, and polyphenols. Some phytochemicals, besides having direct antimicrobial activity, showed an in vitro synergistic effect when tested in combination with conventional antibiotics, modifying antibiotic resistance. Review of the literature showed that phytochemicals represent a possible source of effective, cheap and safe antimicrobial agents, though much work must still be carried out, especially in in vivo conditions to ensure the selection of effective antimicrobial substances with low side and adverse effects. (C) 2016 Elsevier GmbH. All rights reserved.

Item Type: Article
Keywords: Alkaloids Antimicrobial activity Polyphenols Sulfur-containing phytochemicals Terpenoids escherichia-coli o157h7 in-vitro activity synthetic hydroxy isothiocyanates glucosinolate hydrolysis products resistant staphylococcus-aureus camaldulensis essential oils purple prairie clover green tea extracts biofilm formation antimicrobial activity Microbiology
Divisions:
Page Range: pp. 44-68
Journal or Publication Title: Microbiological Research
Journal Index: ISI
Volume: 196
Identification Number: https://doi.org/10.1016/j.micres.2016.12.003
ISSN: 0944-5013
Depositing User: مهندس مهدی شریفی
URI: http://eprints.bmsu.ac.ir/id/eprint/4727

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