Repository of Research and Investigative Information

Repository of Research and Investigative Information

Baqiyatallah University of Medical Sciences

Flavonoids and Chagas' Disease: The Story So Far!

(2017) Flavonoids and Chagas' Disease: The Story So Far! Current Topics in Medicinal Chemistry. pp. 460-466. ISSN 1568-0266

Full text not available from this repository.

Official URL: http://apps.webofknowledge.com/InboundService.do?F...

Abstract

Chagas disease is one of the major health problems in Central and South America, which is caused by the parasitic protozoa, Trypanosoma cruzi. It is commonly transmitted by members of blood-sucking subfamily Triatominae. Chagas disease is associated with cardiac and gastrointestinal manifestations. Up to now, there are no effective vaccines for treatment of Chagas disease and benznidazole and nifurtimox are the only effective anti-Chagas drugs that cause different adverse and side effects. Therefore, much attention has been paid to natural products as novel therapeutic strategies for Chagas disease and its manifestations. Nowadays, some flavonoids could be considered as effective and safe bioactive natural products with potential anti-Chagas activity. Despite the increasing evidence, there is lack of review papers regarding the beneficial effects of flavonoids against Chagas disease and its manifestations. The aim of this paper is to review the available scientific data on the beneficial effects of flavonoids on Chagas disease and its manifestations published over the past two decades. Moreover, we provide an overview on etiology, transmission, epidemiology, clinical manifestations, and current treatment protocols of Chagas disease.

Item Type: Article
Keywords: Chagas disease Flavonoids Heart failure Parasite Triatominae Trypanosoma cruzi induced oxidative stress trypanosoma-cruzi infection trypanocidal activity in-vitro american trypanosomiasis medicinal-plants united-states aerial parts antihemolytic activities active constituents Pharmacology & Pharmacy
Divisions:
Page Range: pp. 460-466
Journal or Publication Title: Current Topics in Medicinal Chemistry
Journal Index: ISI
Volume: 17
Number: 4
Identification Number: https://doi.org/10.2174/1568026616666160824110141
ISSN: 1568-0266
Depositing User: مهندس مهدی شریفی
URI: http://eprints.bmsu.ac.ir/id/eprint/4740

Actions (login required)

View Item View Item