Repository of Research and Investigative Information

Repository of Research and Investigative Information

Baqiyatallah University of Medical Sciences

Distribution of virulence genes and genotyping of CTX-M-15-producing Klebsiella pneumoniae isolated from patients with community-acquired urinary tract infection (CA-UTI)

(2016) Distribution of virulence genes and genotyping of CTX-M-15-producing Klebsiella pneumoniae isolated from patients with community-acquired urinary tract infection (CA-UTI). Microbial Pathogenesis. pp. 244-249. ISSN 0882-4010

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Abstract

Klebsiella pneumoniae is one of the most important agents of community-acquired urinary tract infection (CA-UTI). In addition to extended-spectrum beta-lactamases (ESBLs), a number of virulence factors have been shown to play an important role in the pathogenesis of K. pneumoniae, including capsule, siderophores, and adhesins. Little is known about the genetic diversity and virulence content of the CTX-M-15-producing K. pneumoniae isolated from CA-UTI in Iran. A total of 152 K. pneumoniae isolates were collected from CA-UTI patients in Tehran from September 2015 through April 2016. Out of 152 isolates, 40 (26.3) carried bla(CTX-m-15). PCR was performed for detection of virulence genes in CTX-M-15-producing isolates. Furthermore, all of these isolates were subjected to multiple-locus variable-number of tandem repeat (VNTR) analysis (MLVA). Using MLVA method, 36 types were identified. CIX-M-15-producing K. pneumoniae isolates were grouped into 5 clonal complexes (CCs). Of these isolates, mrkD was the most prevalent virulence gene (95), followed by kpn (60), rmpA (37.5), irp (35), and magA (2.5). No correlation between MLVA types or CCs and virulence genes or antibiotic resistance patterns was observed. Overall, it is thought that CTX-M-15-producing K. pneumoniae strains isolated from CA-UTI have arisen from different clones. (C) 2016 Elsevier Ltd. All rights reserved.

Item Type: Article
Keywords: Klebsiella pneumoniae CTX-M-15 Virulence genes MLVA high-pathogenicity island spectrum-beta-lactamase number tandem repeat escherichia-coli resistance epidemiology prevalence ctx-m-15 strains expression Immunology Microbiology
Divisions:
Page Range: pp. 244-249
Journal or Publication Title: Microbial Pathogenesis
Journal Index: ISI
Volume: 100
Identification Number: https://doi.org/10.1016/j.micpath.2016.10.002
ISSN: 0882-4010
Depositing User: مهندس مهدی شریفی
URI: http://eprints.bmsu.ac.ir/id/eprint/4826

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