Repository of Research and Investigative Information

Repository of Research and Investigative Information

Baqiyatallah University of Medical Sciences

Rapid repair of skin ulcers in diabetic rats using polycaproplactone/gelatin nanon-fiber scaffold

(2019) Rapid repair of skin ulcers in diabetic rats using polycaproplactone/gelatin nanon-fiber scaffold. Koomesh. pp. 535-539. ISSN 16087046 (ISSN)

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Abstract

Introduction: Three-dimensional nano scaffolds by creating a three-dimensional structure similar to the body tissues have created a new perspective on cell culture and tissue repair. The aim of this study was to investigate the effect of polycaprolactone biodegradation scaffold (PCL) in treatment of diabetic wounds. Materials and Methods: Nano PCL-Gelatine scaffold was synthesized by electrospun method. A circular wound (6 mm) was created in skin of 15 BALB/c rats and the rats were divided into 3 groups including: Non-diabetic group (sham), Diabetic group without nano scaffold receiving (control) and diabetic group with nano scaffolds (scaffold). Wound surface area and wound healing were evaluated on the 7th and 14th days using H & E staining with Image J and SPSS softwares. Results: On 7th day, the smallest and highest wound surface was observed in the Scaffold and Control groups respectively (P <0.04). On 14th day, the smallest and highest levels of ulcers were observed in sham and control groups respectively (P <0.00). In the evaluation of wound healing on 7th and 14th days, the highest treatment rates were observed in the Scaffold and sham groups respectively, and on the 14th day there was no significant difference between the two groups (0.40). Conclusion: Polycaprolactone nano-fiber scaffold has a good compatibility with skin ulcers in rats and it can increase the rate and extent of wound healing in diabetic rats. © 2019, Semnan University of Medical Sciences. All rights reserved.

Item Type: Article
Keywords: Diabetes mellitus Polycaprolactone Rats Ulcer gelatin molecular scaffold animal experiment animal model animal tissue Article biodegradation controlled study nonhuman rat skin ulcer wound healing
Divisions:
Page Range: pp. 535-539
Journal or Publication Title: Koomesh
Journal Index: Scopus
Volume: 21
Number: 3
ISSN: 16087046 (ISSN)
Depositing User: مهندس مهدی شریفی
URI: http://eprints.bmsu.ac.ir/id/eprint/484

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