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Repository of Research and Investigative Information

Baqiyatallah University of Medical Sciences

Review Paper: Role of Nitric Oxide on Dopamine Release and Morphine-Dependency

(2016) Review Paper: Role of Nitric Oxide on Dopamine Release and Morphine-Dependency. Basic and Clinical Neuroscience. pp. 283-290. ISSN 2008-126X

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Abstract

The catastrophic effects of opioids use on public health and the economy are documented clearly in numerous studies. Repeated morphine administration can lead to either a decrease (tolerance) or an increase (sensitization) in its behavioral and rewarding effects. Morphine-induced sensitization is a major problem and plays an important role in abuse of the opioid drugs. Studies reported that morphine may exert its effects by the release of nitric oxide (NO). NO is a potent neuromodulator, which is produced by nitric oxide synthase (NOS). However, the exact role of NO in the opioid-induced sensitization is unknown. In this study, we reviewed the role of NO on opioid-induced sensitization in 2 important, rewarding regions of the brain: nucleus accumbens and ventral tegmentum. In addition, we focused on the contribution of NO on opioid-induced sensitization in the limbic system.

Item Type: Article
Keywords: Nitric oxide Opioid Amygdala Ventral tegmental area Nucleus accumbens conditioned place preference ventral tegmental area nicotinic acetylcholine-receptors nucleus-accumbens h-3 dopamine l-arginine rat-brain expression acquisition hippocampal Neurosciences & Neurology
Divisions:
Page Range: pp. 283-290
Journal or Publication Title: Basic and Clinical Neuroscience
Journal Index: ISI
Volume: 7
Number: 4
Identification Number: https://doi.org/10.15412/j.bcn.03070401
ISSN: 2008-126X
Depositing User: مهندس مهدی شریفی
URI: http://eprints.bmsu.ac.ir/id/eprint/4849

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