Repository of Research and Investigative Information

Repository of Research and Investigative Information

Baqiyatallah University of Medical Sciences

Molecular Targets Underlying the Anticancer Effects of Quercetin: An Update

(2016) Molecular Targets Underlying the Anticancer Effects of Quercetin: An Update. Nutrients. p. 19. ISSN 2072-6643

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Abstract

Quercetin, a medicinally important member of the flavonoid family, is one of the most prominent dietary antioxidants. It is present in a variety of foodsincluding fruits, vegetables, tea, wine, as well as other dietary supplementsand is responsible for various health benefits. Numerous pharmacological effects of quercetin include protection against diseases, such as osteoporosis, certain forms of malignant tumors, and pulmonary and cardiovascular disorders. Quercetin has the special ability of scavenging highly reactive species, such as hydrogen peroxide, superoxide anion, and hydroxyl radicals. These oxygen radicals are called reactive oxygen species, which can cause oxidative damage to cellular components, such as proteins, lipids, and deoxyribonucleic acid. Various oxygen radicals play important roles in pathophysiological and degenerative processes, such as aging. Subsequently, several studies have been performed to evaluate possible advantageous health effects of quercetin and to collect scientific evidence for these beneficial health claims. These studies also gather data in order to evaluate the exact mechanism(s) of action and toxicological effects of quercetin. The purpose of this review is to present and critically analyze molecular pathways underlying the anticancer effects of quercetin. Current limitations and future directions of research on this bioactive dietary polyphenol are also critically discussed.

Item Type: Article
Keywords: quercetin cancer prevention diet bioavailability DNA damage polyphenols dietary flavonoids cell-proliferation lipid-peroxidation androgen receptor oxidative damage mammary-cancer neuronal death mek-erk growth inhibition Nutrition & Dietetics
Divisions:
Page Range: p. 19
Journal or Publication Title: Nutrients
Journal Index: ISI
Volume: 8
Number: 9
Identification Number: https://doi.org/10.3390/nu8090529
ISSN: 2072-6643
Depositing User: مهندس مهدی شریفی
URI: http://eprints.bmsu.ac.ir/id/eprint/4919

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