Abstract

High glucose range causes oxidative stress as a result of increased production of reactive oxygen species. Co Q10 inhibits certain enzymes involved in the formation of free radicals and hence attenuates oxidative stress. 45 male adult rats were selected and divided in to three groups. Control rats fed on normal diet ad libitum with i.p. injection of saline daily. Fructose fed control rat group fed on normal diet and supplemented by 10 fructose in drinking water ad libitum with i.p. injection of saline daily. Third group as Fructose fed rats treated with coenzyme Q10 (10 mg/kg i.p. daily). The food and water intake of Fructose Fed group was significantly higher than other two studied groups. The serum P levels were found significantly increased in CoQ10 treated fructose fed rats compared to the fructose fed rats. The serum ALP levels were found decreased in CoQ10 treated fructose fed rats compared to the fructose fed rats. There were no significant changes on serum Mg. using Coenzyme Q10 had protective effects on diabetic like conditions.