Repository of Research and Investigative Information

Repository of Research and Investigative Information

Baqiyatallah University of Medical Sciences

Adjunctive Therapy with Curcumin for Peptic Ulcer: a Randomized Controlled Trial

(2016) Adjunctive Therapy with Curcumin for Peptic Ulcer: a Randomized Controlled Trial. Drug Research. pp. 444-448. ISSN 2194-9379

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Abstract

Background: Curcumin, the bioactive ingredient of turmeric, has been shown to improve the treatment of peptic ulcer (PU) in animal studies. However, clinical studies confirming this effect of curcumin have been scant. Objective: To assess the efficacy of adjunctive therapy with curcumin on the eradication of Helicobacter pylori infection and severity of dyspepsia in patients with PU. Methods: In this randomized double-blind placebo-controlled parallel-group trial, patients diagnosed with PU were assigned to standard H. pylori eradication triple therapy with clarithromycin (500mg b.i.d.), amoxicillin (1000mg b.i.d.) and pantoprazole (40mg b.i.d.), and randomized to receive either curcumin (500mg/day) or placebo as adjunct to standard treatment. Severity of dyspepsia symptoms was evaluated using the Hong Kong dyspepsia index (HKDI). Eradication of H. pylori infection was assessed using the urea breath test (UBT) at 4 weeks following the end of treatment. Results: Adjunctive therapy with curcumin was associated with a greater improvement of dyspepsia symptoms according to the HKDI score (change score: -12.902.81 vs. -9.60 +/- 3.39 in the curcumin and control group, respectively; p<0.001). The number of subjects whose dyspepsia was resolved during the course of treatment was significantly higher in the curcumin (27.6) vs. placebo (6.7) group (p=0.042). Nevertheless, the results of UBT test showed equal rate (73.3) of H. pylori eradication in the study groups. Curcumin was safe during the course of trial. Conclusion: Addition of curcumin on top of the standard anti-helicobacter regimen in patients with PU is safe and improves dyspepsia symptoms but has no enhancing effect on the eradication of H. pylori infection.

Item Type: Article
Keywords: peptic ulcer dyspepsia helicobacter pylori curcumin randomized controlled trial helicobacter-pylori infection placebo-controlled trial quality-of-life nf-kappa-b double-blind metabolic syndrome epithelial-cells management piperine bioavailability Pharmacology & Pharmacy Chemistry
Divisions:
Page Range: pp. 444-448
Journal or Publication Title: Drug Research
Journal Index: ISI
Volume: 66
Number: 8
Identification Number: https://doi.org/10.1055/s-0042-109394
ISSN: 2194-9379
Depositing User: مهندس مهدی شریفی
URI: http://eprints.bmsu.ac.ir/id/eprint/4934

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