Repository of Research and Investigative Information

Repository of Research and Investigative Information

Baqiyatallah University of Medical Sciences

Analyzing the effect of MicroRNAs on Hepatogenic differentiation of Mesenchymal stem cells

(2016) Analyzing the effect of MicroRNAs on Hepatogenic differentiation of Mesenchymal stem cells. International Journal of Advanced and Applied Sciences. pp. 69-74. ISSN 2313-626X

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Abstract

This research aims at analyzing the effect of microRNAs on hepatogenic Differentiation of mesenchymal stem cells. According to the results, miR-1246, miR-1290, miR-148a, miR-30a, miR-424 and miR-542-5p were definitely overexpressed during hepatic differentiation of hMSCs. Also the results indicate that ectopic overexpression of miR-122 cannot initiate hepatic differentiation of hMSCs. In other words, hMSCs can be converted into functional hepatocytes only if all the miRs (miR-122, miR-1246, miR-1290, miR-148a, miR-30a, miR-424, and miR-542-5p) are used. (C) 2016 The Authors. Published by IASE.

Item Type: Article
Keywords: Hepatogenic Mesenchymal stem cells MicroRNAs hepatic differentiation liver-regeneration hepatocyte proliferation cycle progression overexpression inhibition Science & Technology - Other Topics
Divisions:
Page Range: pp. 69-74
Journal or Publication Title: International Journal of Advanced and Applied Sciences
Journal Index: ISI
Volume: 3
Number: 7
Identification Number: https://doi.org/10.21833/ijaas.2016.07.011
ISSN: 2313-626X
Depositing User: مهندس مهدی شریفی
URI: http://eprints.bmsu.ac.ir/id/eprint/4953

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