Repository of Research and Investigative Information

Repository of Research and Investigative Information

Baqiyatallah University of Medical Sciences

Helicobacter pylori isolated from Iranian drinking water: vacA, cagA, iceA, oipA and babA2 genotype status and antimicrobial resistance properties

(2016) Helicobacter pylori isolated from Iranian drinking water: vacA, cagA, iceA, oipA and babA2 genotype status and antimicrobial resistance properties. Febs Open Bio. pp. 433-441. ISSN 2211-5463

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Abstract

Despite the clinical importance of Helicobacter pylori in human gastric disorders, its exact route of transmission is still uncertain. Based on the contentious hypothesis and findings of previous investigations, water may play an important role in the transmission of H. pylori to humans. This study was carried out to investigate the vacA, cagA, oipA, iceA and babA2 genotype status and antimicrobial resistance properties of H. pylori strains isolated from the drinking water samples of four major provinces in Iran. A total of 400 drinking water samples were cultured and tested. H. pylori-positive strains were analyzed for the presence of various genotypes and antimicrobial resistance. Twelve of 400 (3) water samples were positive for H. pylori. Samples from Isfahan province had the highest, while those from Shiraz had the lowest prevalence of H. pylori. The seasonal distribution was also determined, with the highest prevalence of bacteria in the summer season (7.36). H. pylori strains harbored the highest levels of resistance against ampicillin (100), erythromycin (75), clarithromycin (75), and trimethoprim (58.3). The most commonly detected genotypes were vacAs1a (83.3), vacAm1a (66.6), vacAs2 (50) and cagA (50). The presence of similar genotypes in the H. pylori strains of drinking water and those of human clinical samples suggest that contaminated water maybe the sources of bacteria. Spiramycin and furazolidone are suggested for the treatment of cases of H. pylori infection.

Item Type: Article
Keywords: antibiotic resistance properties drinking water genotypes genotyping Helicobacter pylori Iran prevalence strains transmission infection epidemiology genes population biofilms disease genomes Biochemistry & Molecular Biology
Divisions:
Page Range: pp. 433-441
Journal or Publication Title: Febs Open Bio
Journal Index: ISI
Volume: 6
Number: 5
Identification Number: https://doi.org/10.1002/2211-5463.12054
ISSN: 2211-5463
Depositing User: مهندس مهدی شریفی
URI: http://eprints.bmsu.ac.ir/id/eprint/5026

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