Repository of Research and Investigative Information

Repository of Research and Investigative Information

Baqiyatallah University of Medical Sciences

Molecular mechanisms of curcumins suppressing effects on tumorigenesis, angiogenesis and metastasis, focusing on NF-kappa B pathway

(2016) Molecular mechanisms of curcumins suppressing effects on tumorigenesis, angiogenesis and metastasis, focusing on NF-kappa B pathway. Cytokine & Growth Factor Reviews. pp. 21-29. ISSN 1359-6101

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Abstract

NF-kappa B pathway has long been considered as one of the potent prototypical pro-inflammatory signaling pathway and its role in several aspects of human health has been established. Recent studies have suggested that NF-kappa B activation is the master key in early development and pathobiology of several Cancers. Curcumin is a polyphenolic phytochemical compound with several stablished anti-inflammatory properties and is known to exert its anti-inflammatory effects mostly by interrupting NF-kappa B signaling pathway at multiple stages. Here we tried to provide a summary of recent finding, focusing on introducing NF-kappa B signaling pathways and its potential mechanism involved in development of several types of Cancers. (C) 2015 Elsevier Ltd. All rights reserved.

Item Type: Article
Keywords: NF-kappa B Cancer Curcumin Inflammation t-cells transcriptional regulation endothelial-cells prostate-cancer innate immunity tnf-alpha in-vitro inflammation activation apoptosis Biochemistry & Molecular Biology Cell Biology
Divisions:
Page Range: pp. 21-29
Journal or Publication Title: Cytokine & Growth Factor Reviews
Journal Index: ISI
Volume: 28
Identification Number: https://doi.org/10.1016/j.cytogfr.2015.12.004
ISSN: 1359-6101
Depositing User: مهندس مهدی شریفی
URI: http://eprints.bmsu.ac.ir/id/eprint/5050

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