Repository of Research and Investigative Information

Repository of Research and Investigative Information

Baqiyatallah University of Medical Sciences

Resveratrol and the mitochondria: From triggering the intrinsic apoptotic pathway to inducing mitochondrial biogenesis, a mechanistic view

(2016) Resveratrol and the mitochondria: From triggering the intrinsic apoptotic pathway to inducing mitochondrial biogenesis, a mechanistic view. Biochimica Et Biophysica Acta-General Subjects. pp. 727-745. ISSN 0304-4165

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Abstract

Background: Mitochondria, the power plants of the cell, are known as a cross-road of different cellular signaling pathways. These cytoplasmic double-membraned organelles play a pivotal role in energy metabolism and regulate calcium flux in the cells. It is well known that mitochondrial dysfunction is associated with different diseases such as neurodegeneration and cancer. A growing body of literature has shown that polyphenolic compounds exert direct effects on mitochondrial ultra-structure and function. Resveratrol is known as one of the most common bioactive constituents of red wine, which improves mitochondrial functions under in vitro and in vivo conditions. Scope of review: This paper aims to review the molecular pathways underlying the beneficial effects of resveratrol on mitochondrial structure and functions. In addition, we discuss the chemistry and main sources of resveratrol. Major conclusions: Resveratrol represents the promising effects on mitochondria in different experimental models. However, there are several reports on the detrimental effects elicited by resveratrol on mitochondria. General significance: An understanding of the chemistry and source of resveratrol, its bioavailability and the promising effects on mitochondria brings a new hope to therapy of mitochondria! dysfunction-related diseases. (C) 2016 Elsevier B.V. All rights reserved.

Item Type: Article
Keywords: Mitochondria Natural products Oxidative stress Polyphenols Resveratrol attenuates oxidative stress natural-product present cell-cycle progression breast-cancer cells trans-resveratrol transcription factor in-vitro down-regulation nitric-oxide caloric restriction Biochemistry & Molecular Biology Biophysics
Divisions:
Page Range: pp. 727-745
Journal or Publication Title: Biochimica Et Biophysica Acta-General Subjects
Journal Index: ISI
Volume: 1860
Number: 4
Identification Number: https://doi.org/10.1016/j.bbagen.2016.01.017
ISSN: 0304-4165
Depositing User: مهندس مهدی شریفی
URI: http://eprints.bmsu.ac.ir/id/eprint/5061

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