Abstract

Background and Aim: Depression is a common psychiatric disorder with a high prevalence in military personnel. Recently, the relationship between depression and some hormones has been reported. In current study, the serum levels of anti-thyroid peroxidase (anti-TPO), triiodothyronine (T3), thyroxin (T4) and thyroid-stimulating hormone (TSH) was assessed in people with depression and compared with healthy control adults. Methods: In this case–control study, 45 people with depression who were diagnosed using the Beck depression test and DSM5, were referred to a military hospital. A total of 45 healthy participants who were matched according gender and age with the depression group, were also enrolled. Levels of anti-TPO, T4, T3 and TSH were measured and compared in the two groups. Results: The mean ±standard deviation age was 36.55±11.42 years in the case group and 35.92±11.58 years in the matched control group. There was no significant difference in the mean serum level of antithyroid peroxidase, T3, T4 and TSH between the groups (P≥0.05). There was no linear correlation between antithyroid peroxidase levels and depression severity. Conclusion: As there was not difference regarding anti-TPO antibody levels between the depressed and healthy groups, it appears that anti-TPO antibody may not have a role in depression. © 2019 Baqiyatallah University of Medical Sciences. All rights reserved.