(2016) Detection of Critical Genes Associated with Overall Survival (OS) and Progression-Free Survival (PFS) in Reconstructed Canine B-Cell Lymphoma Gene Regulatory Network (GRN). Cancer Investigation. pp. 70-79. ISSN 0735-7907
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Abstract
Canine B-cell lymphoma GRN was reconstructed from gene expression data in the STRING and MiMI databases. Critical genes of networks were identified and correlations of critical genes with overall survival (OS) and progression-free survival (PFS) were evaluated. Significant changes were detected in the expressions of GLUL, CD44, CD79A, ARF3, FOS, BLOC1S1, FYN, GZMB, GALNT3, IFI44, CD3G, GNG2, ESRP1, and CCND1 in the STRING network and of PECAM1, GLUL, CD44, GDI1, E2F4, TLE1, CD79A, UCP2, CCND1, FYN, RHOQ, BIN1, and A2M in the MiMI network. Final survival analysis highlighted CCND1 and FOS as genes with significant correlations with OS and PFS.
| Item Type: | Article |
|---|---|
| Keywords: | Progression-free survival (PFS) Critical genes Overall survival (OS) Canine lymphoma Gene regulatory network (GRN) cyclin d1 expression prognostic-significance germinal center cd44 expression c-fos ccnd1 amplification polymorphism proteins tumors Oncology |
| Divisions: | |
| Page Range: | pp. 70-79 |
| Journal or Publication Title: | Cancer Investigation |
| Journal Index: | ISI |
| Volume: | 34 |
| Number: | 2 |
| Identification Number: | https://doi.org/10.3109/07357907.2015.1114120 |
| ISSN: | 0735-7907 |
| Depositing User: | مهندس مهدی شریفی |
| URI: | http://eprints.bmsu.ac.ir/id/eprint/5109 |
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