Repository of Research and Investigative Information

Repository of Research and Investigative Information

Baqiyatallah University of Medical Sciences

Association of HFE gene mutations with nonalcoholic fatty liver disease in the Iranian population

(2016) Association of HFE gene mutations with nonalcoholic fatty liver disease in the Iranian population. Cellular and Molecular Biology. pp. 123-128. ISSN 0145-5680

[img] Text
Association of HFE gene mutations with nonalcoholic fatty liver disease in the Iranian population.pdf

Download (411kB)

Official URL: http://apps.webofknowledge.com/InboundService.do?F...

Abstract

To determine whether the HFE gene variants H63D and C282Y are associated with NAFLD in persons with type 2 diabetes, we conducted a case-control study including 145 case of NAFLD patients with a history of type 2 diabetes and 145 matching control. The genomic DNA was extracted from the peripheral venous blood and the genotyping of HFE gene mutations was analyzed using the PCR-RFLP technique. Statistical analysis was performed using SPSS 12.0 software by chi 2 test, t test and ANOVA (P<0.05). Data showed no increased frequency of HFE mutations in persons with type 2 diabetes and no association between H63D mutation and NAFLD in the study population. Also, we analyzed index of physiological variables including FBS, lipid profile (TC, TG, LDL-C, and HDL-C), BMI, HbA1c, and micro albuminuria and Cr levels). Data showed there are no relationship between these indexes and HFE gene mutations and either NAFLD as a complication of diabetes. But our results showed a relationship between C282Y mutation and NAFLD in persons with type 2 diabetes. C282Y mutation might be a genetic marker of NAFLD in Iranian population.

Item Type: Article
Keywords: Type 2 diabetes Nonalcoholic fatty liver disease HFE gene H63D C282Y mutations type-2 diabetes-mellitus hereditary hemochromatosis iron overload insulin-resistance relative contribution increased prevalence hepatic iron fibrosis steatohepatitis c282y Biochemistry & Molecular Biology Cell Biology
Divisions:
Page Range: pp. 123-128
Journal or Publication Title: Cellular and Molecular Biology
Journal Index: ISI
Volume: 62
Number: 12
Identification Number: https://doi.org/10.14715/cmb/2016.62.12.21
ISSN: 0145-5680
Depositing User: مهندس مهدی شریفی
URI: http://eprints.bmsu.ac.ir/id/eprint/5150

Actions (login required)

View Item View Item