Repository of Research and Investigative Information

Repository of Research and Investigative Information

Baqiyatallah University of Medical Sciences

Assessment of Treg/Th17 axis role in immunopathogenesis of chronic injuries of mustard lung disease

(2016) Assessment of Treg/Th17 axis role in immunopathogenesis of chronic injuries of mustard lung disease. Journal of Receptors and Signal Transduction. pp. 531-541. ISSN 1079-9893

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Abstract

Purpose: Sulfur mustard (SM) lung is a heterogeneous disease associated with abnormal inflammatory immune responses. The Th17/Treg axis imbalance is associated with the pathogenesis of chronic inflammatory pulmonary disease. We aimed to determine the distribution of different Th17 and Treg cells in patients with SM lung and chronic obstructive pulmonary disease (COPD) and evaluate the clinical implications in this homeostasis. Methods: In this analytical cross-sectional study, CD4(+) Foxp3(+) Treg and CD4(+) IL-17(+) Th17 cells were measured in peripheral blood mononuclear cells (PBMCs) and transbronchial biopsy (TBB) samples of 15 SM-exposed patients, 12 COPD and 13 healthy controls (HCs). The potential correlation between the ratio of Th17/Tregs and lung function was evaluated with multivariate logistic regression (MLR) analysis. Results: The frequency of CD4(+) FoxP3(+) Tregs and CD4(+) IL17(+) Th17 was increased similar to 1.7-fold (8.71/4.95) and similar to 2.7-fold (1.028/0.371) respectively, in the PBMC of SM patients compared with the health controls (p<0.001). The results indicated that there were increases in the frequency of Th17 and Tregs cells in the patients with COPD versus the HC, that is, similar to 2.6-fold (0.987/0.371) and similar to 1.4-fold (7.12/4.95), respectively; but they did not reach to SM level (p >= 0.05). Moreover, in the TBB samples, the CD4(+) IL-17(+) Th17 and CD4(+) FoxP3(+) Tregs numbers were significantly higher in SM and COPD patients than HC (p<0.05). The Th17 and Treg cells were inversely correlated with forced expiratory volume in 1s (FEV1) (r = -0.351, p = 0.001; r = -0.344, p = 0.021) and FEV1/FVC (r = -0.44, p = 0.001; r = -0.302, p = 0.011), respectively. Instead, positive correlations were found between Treg/Th17 ratios and forced FEV1 pred (r = 0.156, p = 0.007), as well as FEV1/FVC ratio (r = 0.334, p = 0.006). Conclusions: The imbalance of Th17/Treg has a key role in immunopathogenesis of chronic phase of mustard lung disease.

Item Type: Article
Keywords: Mustard lung disease COPD Th17 cells regulatory T cells immunopathogenesis regulatory t-cells obstructive pulmonary-disease sulfur mustard peripheral-blood bal fluid th17 imbalance lymphocytes expression il-17 Biochemistry & Molecular Biology Cell Biology
Divisions:
Page Range: pp. 531-541
Journal or Publication Title: Journal of Receptors and Signal Transduction
Journal Index: ISI
Volume: 36
Number: 5
Identification Number: https://doi.org/10.3109/10799893.2016.1141953
ISSN: 1079-9893
Depositing User: مهندس مهدی شریفی
URI: http://eprints.bmsu.ac.ir/id/eprint/5168

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