(2016) Hepatitis delta virus facilitates the selection of hepatitis B virus mutants in vivo and functionally impacts on their replicative capacity in vitro. Clinical Microbiology and Infection. p. 6. ISSN 1198-743X
![[img]](http://eprints.bmsu.ac.ir/style/images/fileicons/text.png) |
Text
Hepatitis delta virus facilitates the selection of hepatitis B virus mutants in vivo and functionally impacts on their replicative capacity in vitro.pdf Download (1MB) |
Abstract
To identify molecular interactions between hepatitis B virus (HBV) and hepatitis delta virus (HDV), HBV sequences were analysed in HBV/HDV-infected patients. Characteristic amino acid substitutions were found in cytosolic domains of hepatitis B surface antigen (HBsAg), in contrast to HBV-mono-infected controls. The functional impact of HDV on the replication of wild-type and mutant HBV was assessed in vitro. HDV cotransfection significantly reduced the replication of HBV strains containing precore or basal core promoter mutations, and HBV polymerase or surface antigen mutants affected HDV replication in vitro. Conclusively, our study revealed distinct HBsAg mutational patterns in HBV/HDV-infected patients and novel functional interactions between HBV and HDV. (C) 2015 European Society of Clinical Microbiology and Infectious Diseases. Published by Elsevier Ltd. All rights reserved.
| Item Type: | Article |
|---|---|
| Keywords: | Basal core promoter HBsAg hepatitis B virus hepatitis delta virus precore basal core promoter envelope proteins large-isoform mutations precore glycosylation polymerase activation particles secretion Infectious Diseases Microbiology |
| Divisions: | |
| Page Range: | p. 6 |
| Journal or Publication Title: | Clinical Microbiology and Infection |
| Journal Index: | ISI |
| Volume: | 22 |
| Number: | 1 |
| Identification Number: | https://doi.org/10.1016/j.cmi.2015.09.020 |
| ISSN: | 1198-743X |
| Depositing User: | مهندس مهدی شریفی |
| URI: | http://eprints.bmsu.ac.ir/id/eprint/5228 |
Actions (login required)
 |
View Item |