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Baqiyatallah University of Medical Sciences

Neuroprotective Effects of Quercetin: From Chemistry to Medicine

(2016) Neuroprotective Effects of Quercetin: From Chemistry to Medicine. Cns & Neurological Disorders-Drug Targets. pp. 964-975. ISSN 1871-5273

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Abstract

Neurodegenerative diseases are the leading cause of disability in the elderly. Growing evidence suggests that oxidative stress, which is associated with aging, is the basis of most neurodegenerative disorders; and polyphenols, acting as antioxidant agents, reduce the risk of neurodegenerative diseases. Quercetin is a flavonoid occurring in many plant foods commonly consumed as part of a regular diet. It shows a number of biological properties connected to its antioxidant activity. This review assesses the molecular structure of quercetin, its food sources and bioavailability. Moreover, the main results obtained from in vitro studies, observing the mechanisms of action through which quercetin exerts its antioxidant activity, are reported. However, most of these effects have only been observed in vitro and clinical studies are lacking.

Item Type: Article
Keywords: Antioxidant Flavonoid Neurodegeneration Oxidative stress Quercetin induced oxidative stress endoplasmic-reticulum stress coronary-heart-disease o-glycosyl flavonoids l. osbeck juice in-vivo mitochondrial dysfunction antioxidant capacity lipid-peroxidation cancer-cells Neurosciences & Neurology Pharmacology & Pharmacy
Divisions:
Page Range: pp. 964-975
Journal or Publication Title: Cns & Neurological Disorders-Drug Targets
Journal Index: ISI
Volume: 15
Number: 8
Identification Number: https://doi.org/10.2174/1871527315666160813175406
ISSN: 1871-5273
Depositing User: مهندس مهدی شریفی
URI: http://eprints.bmsu.ac.ir/id/eprint/5233

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