Repository of Research and Investigative Information

Repository of Research and Investigative Information

Baqiyatallah University of Medical Sciences

The footprint of TGF-beta in airway remodeling of the mustard lung

(2015) The footprint of TGF-beta in airway remodeling of the mustard lung. Inhalation Toxicology. pp. 745-753. ISSN 0895-8378

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Abstract

Mustard lung is a major pulmonary complication in individuals exposed to sulfur mustard (SM) gas during the Iran-Iraq war. It shares common pathological and clinical features with some chronic inflammatory lung disorders, particularly chronic obstructive pulmonary disease (COPD). Airway remodeling, which is one of the main causes of lung dysfunction and the dominant phenomenon of chronic pulmonary diseases, is seen in the mustard lung. Among all mediators involved in the remodeling process, the transforming growth factor (TGF)- plays a pivotal role in lung fibrosis and consequently in the airway remodeling. Regarding the high levels of this mediator detected in mustard lung patients, in the present study, we have discussed the possible roles of TGF- in airway remodeling (including epithelial layer damage, subepithelial fibrosis and angiogenesis). Finally, based on TGF- targeting, we have reviewed new airway remodeling therapeutic approaches.

Item Type: Article
Keywords: Airway remodeling COPD sulfur mustard TGF-beta growth-factor-beta obstructive pulmonary-disease sulfur mustard transforming growth-factor-beta-1 epithelial-cells increased expression mediated activation signaling pathway cigarette-smoke gene-expression Toxicology
Divisions:
Page Range: pp. 745-753
Journal or Publication Title: Inhalation Toxicology
Journal Index: ISI
Volume: 27
Number: 14
Identification Number: https://doi.org/10.3109/08958378.2015.1116645
ISSN: 0895-8378
Depositing User: مهندس مهدی شریفی
URI: http://eprints.bmsu.ac.ir/id/eprint/5269

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