Repository of Research and Investigative Information

Repository of Research and Investigative Information

Baqiyatallah University of Medical Sciences

Effect of radiation therapy on wound healing

(2019) Effect of radiation therapy on wound healing. Acta Med Iran. pp. 167-172. ISSN 00446025 (ISSN)

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Many studies were carried out to improve sophisticated approaches to accelerate wound healing processes and also, wound healing is extensively discussed in the medicinal literature. In this study, we aimed to investigate the wound healing of mice with visible radiation (630 nm). In this study, 28 male mice were used and randomly divided into 4 groups. All samples were subjected to a 6 mm skin incision. Four groups were tested as following 10 minutes (First group), 20 minutes (Second group), 30 minutes (Third group) light exposure and no light radiation (control group), respectively. Wound contraction was analyzed by taking photos and Image J software. All mice were sacrificed, and samples were evaluated by Hematoxylin and Eosin staining after one week. The results demonstrated that the experimental group with 20 min.light irradiation had a much faster effect of wound healing than the 10, 30 minute and control group. The results showed that 20 minutes of light exposure group was the best treatment. © 2019 Tehran University of Medical Sciences. All rights reserved.

Item Type: Article
Keywords: Mice Radiation therapy Skin Wound healing animal cell animal experiment animal model animal tissue Article controlled study descriptive research epithelization histology light exposure male mouse nonhuman randomized controlled trial skin incision tensiometry time factor wound contraction wound healing rate
Page Range: pp. 167-172
Journal or Publication Title: Acta Med Iran
Journal Index: Scopus
Volume: 57
Number: 3
Identification Number:
ISSN: 00446025 (ISSN)
Depositing User: مهندس مهدی شریفی

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