Repository of Research and Investigative Information

Repository of Research and Investigative Information

Baqiyatallah University of Medical Sciences

Efficacy of Tiotropium Bromide and Rehabilitation Treatment on Pulmonary Function of Patients With Sulfur Mustard Lung Injury

(2015) Efficacy of Tiotropium Bromide and Rehabilitation Treatment on Pulmonary Function of Patients With Sulfur Mustard Lung Injury. Iranian Red Crescent Medical Journal. p. 6. ISSN 2074-1804

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Abstract

Background: Chronic pulmonary complication is the most common delayed toxic effect of sulfur mustard (SM) and it has no treatment so far. Objectives: To evaluate short-term therapeutic effects of inhaled tiotropium bromide and pulmonary rehabilitation on pulmonary function of patients with SM induced lung injury. Patients and Methods: In a randomized clinical trial, using convenient sampling method, 54 patients with chronic lung disease due to SM exposure were recruited in Baqiyatallah General Hospital, Tehran, Iran for a period of 2-month study. They were randomly divided into 3 groups of 18 participants each. Group 1 received routine drugs (Serevent, Flixotide), pulmonary rehabilitation 30 minutes/2 times a week, and tiotropium bromide 18 mu g/day. Group 2 was treated with routine drugs and pulmonary rehabilitation and group 3 was only on the routine drugs. cardiopulmonary exercise test (CPET), plethysmographic measurements, and respiratory symptoms evaluation were performed before and after medical intervention. Results: In group 1, compared to group 3, significant differences were found with regard to symptoms of cough (difference between the first and last visit in group 1: Diff1 Diff3 = -0.3, P = 0.01) and nocturnal dyspnea (Diff1 = -1.6, Diff3 = 0.0, P = 0.01), likewise, compared to group 2, significant differences were found with regard to lung function parameters of forced vital capacity (Diff1 = 3.0, Diff 2 = -3.5, P = 0.03), forced expiratoryvolume in one second (Diff1 = 3.9, Diff2 = -5.6, P = 0.009), maximal mid-expiratory flow rate 25%-75%(Diff = 1.5, Diff 2 = -3.2, P = 0.007) and peak expiratory flow (Diff1 = -2.06, Diff 2 = -4.3, P = 0.04). Total lung capacity (Diff 2 = 9.28, Diff 3 = 42.07, P = 0.02) and residual volume (Diff2 = 32.1, Diff3 = -27.6, P = 0.04) were increased in group 2 compared to group 3. There were no significant differences with regard to CPET results among all groups (P > 0.05). Conclusions: Inhalation of tiotropium bromide in combination with pulmonary rehabilitation could improve some plethysmographic lung volumes and clinical outcomes in patients with chronic pulmonary disease due to SM. Short-term prescription of pulmonary rehabilitation has no effect on CPET of patients.

Item Type: Article
Keywords: Bronchiolitis Obliterans Exercise Test Tiotropium Plethysmography Rehabilitation Sulfur Mustard bronchiolitis obliterans copd disease exposure standardization hyperinflation complications limitation outcomes agents General & Internal Medicine
Divisions:
Page Range: p. 6
Journal or Publication Title: Iranian Red Crescent Medical Journal
Journal Index: ISI
Volume: 17
Number: 12
Identification Number: https://doi.org/10.5812/ircmj.20026
ISSN: 2074-1804
Depositing User: مهندس مهدی شریفی
URI: http://eprints.bmsu.ac.ir/id/eprint/5272

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