Repository of Research and Investigative Information

Repository of Research and Investigative Information

Baqiyatallah University of Medical Sciences

Molecular mechanisms underlying anticancer effects of myricetin

(2015) Molecular mechanisms underlying anticancer effects of myricetin. Life Sciences. pp. 19-25. ISSN 0024-3205

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Abstract

Dietary guidelines published in the past two decades have acknowledged the beneficial effects of myricetin, an important and common type of herbal flavonoid, against several human diseases such as inflammation, cardiovascular pathologies, and cancer. An increasing number of studies have shown the beneficial effects of myricetin against different types of cancer by modifying several cancer hallmarks including aberrant cell proliferation, signaling pathways, apoptosis, angiogenesis, and tumor metastasis. Most importantly, myricetin interacts with oncoproteins such as protein Idnase B (PKB) (Akt), Fyn, MEK1, and JAK1-STAT3 (Janus kinase-signal transducer and activator of transcription 3), and it attenuates the neoplastic transformation of cancer cells. In addition, myricetin exerts antimitotic effects by targeting the overexpression of cyclin-dependent kinase 1 (CDK1) in liver cancer. Moreover, it also targets the mitochondria and promotes different kinds of cell death in various cancer cells. In the present paper, a critical review of the available literature is presented to identify the molecular targets underlying the anticancer effects of myricetin. (C) 2015 Elsevier Inc. All rights reserved.

Item Type: Article
Keywords: Myricetin Cdk1 Akt Erk1 and Erk2 Mek1 Jak1 Stat3 Ap-1 Apoptosis Metastasis performance liquid-chromatography activity-guided isolation cell-cycle checkpoints necrosis-factor-alpha peltatum torr. engl in-vitro cancer-cells peltiphyllum-peltatum signaling pathway ethanolic extract Research & Experimental Medicine Pharmacology & Pharmacy
Divisions:
Page Range: pp. 19-25
Journal or Publication Title: Life Sciences
Journal Index: ISI
Volume: 142
Identification Number: https://doi.org/10.1016/j.lfs.2015.10.004
ISSN: 0024-3205
Depositing User: مهندس مهدی شریفی
URI: http://eprints.bmsu.ac.ir/id/eprint/5288

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