Repository of Research and Investigative Information

Repository of Research and Investigative Information

Baqiyatallah University of Medical Sciences

Comparison of effect of intraperitoneal vs. intra-accumbal injection of memantine on response to acute stress in female NMRI mice

(2015) Comparison of effect of intraperitoneal vs. intra-accumbal injection of memantine on response to acute stress in female NMRI mice. Physiology and Pharmacology. pp. 383-395. ISSN 2476-5236

[img] Text
Comparison of effect of intraperitoneal vs. intra-accumbal injection of memantine on response to acute stress in female NMRI mice.pdf

Download (763kB)

Official URL: http://apps.webofknowledge.com/InboundService.do?F...

Abstract

Introduction: In this study, the effect of memantine administration into the nucleus accumbens on the metabolic changes induced by acute stress in female mice was evaluated. Methods: Intra-accumbens unilateral or bilateral canulation was performed. One week after recovery, a group of animals were given memantine (1, 0.5, and 0.1 mu g/mouse) five min before stress induction intra-accumbally, and the other group received it (1, 0.5 and 0.1 mg/kg) 30 min before stress intraperitoneally. Food and water intake, weight of fecal material, and the delay time before eating were measured as metabolic parameters after stress induction. Results: Acute stress reduced water and food intake, fecal matter, and the delay time before eating. Intraperitoneal memantine injections augmented the stress effect on water intake, but inhibited its effect on food intake at dose of 0.1 mg/kg and had no impact on defecation. The drug induced anorexia especially at dose of 1 mg/kg. On the other hand, intra-accumbens memantine injections reduced water intake when the drug was injected in the left side. Moreover, memantine injections inhibited or enhanced the effects of stress on water intake, food intake and defecation in a dose-and location-dependent manner, and also increased the delay time before eating. Conclusion: Memantine inhibits or enhances the effects of acute stress dose-dependently. In addition, it seems that there is asymmetry in nucleus accumbens response.

Item Type: Article
Keywords: Memantine Nucleus accumbens Acute stress NMDA glutamate receptor nucleus-accumbens glutamate receptors synaptic plasticity feeding-behavior nmda rats brain expression disorders food Physiology
Divisions:
Page Range: pp. 383-395
Journal or Publication Title: Physiology and Pharmacology
Journal Index: ISI
Volume: 18
Number: 4
ISSN: 2476-5236
Depositing User: مهندس مهدی شریفی
URI: http://eprints.bmsu.ac.ir/id/eprint/5305

Actions (login required)

View Item View Item