Repository of Research and Investigative Information

Repository of Research and Investigative Information

Baqiyatallah University of Medical Sciences

Multipotent bone marrow stromal cell therapy promotes endogenous cell proliferation following ischemic stroke

(2015) Multipotent bone marrow stromal cell therapy promotes endogenous cell proliferation following ischemic stroke. Clinical and Experimental Pharmacology and Physiology. pp. 1158-1167. ISSN 1440-1681

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Abstract

Despite extensive research over the years, there still exists some debate as to what constitutes the optimal therapeutic strategy to promote recovery following stroke. Due to the complexity of injured brain pathophysiology, treatment approaches should ideally address numerous factors, ultimately aiming to promote tissue protection, axonal regrowth and functional recovery. This study extends the understanding of the effects of bone marrow stromal cell (BMSC) treatment following experimentally induced ischemic stroke in rats. Focal ischemic brain injury was experimentally induced in rats by placing a preformed clot into the middle cerebral artery. Animals were injected intravenously with BMSCs at 24h after stroke and were killed 7days post injury. When administered BMSCs following stroke, the neurological outcome was significantly improved relative to controls. There was an increase in the number of BMSCs labelled with BrdU present in the injured hemisphere of the brain compared to the non-injured side. Furthermore, administration of BMSCs also led to increases in astrocytosis, vascularization and endogenous proliferation. These findings provide insight into the mechanisms of action of BMSC treatment and further argue for the therapeutic potential of BMSCs as an effective treatment following cerebral stroke.

Item Type: Article
Keywords: bone marrow stromal cell brain stroke transplantation mesenchymal stem-cells blood-brain-barrier cerebral-artery occlusion functional recovery rats transplantation injury arteriogenesis combination simvastatin Pharmacology & Pharmacy Physiology
Divisions:
Page Range: pp. 1158-1167
Journal or Publication Title: Clinical and Experimental Pharmacology and Physiology
Journal Index: ISI
Volume: 42
Number: 11
Identification Number: https://doi.org/10.1111/1440-1681.12466
ISSN: 1440-1681
Depositing User: مهندس مهدی شریفی
URI: http://eprints.bmsu.ac.ir/id/eprint/5328

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