Repository of Research and Investigative Information

Repository of Research and Investigative Information

Baqiyatallah University of Medical Sciences

Comparative trial of Aloe vera/olive oil combination cream versus phenytoin cream in the treatment of chronic wounds

(2015) Comparative trial of Aloe vera/olive oil combination cream versus phenytoin cream in the treatment of chronic wounds. Journal of Wound Care. pp. 459-465. ISSN 0969-0700

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Abstract

Objective: Aloe vera is a medicinal plant that has been traditionally used to accelerate wound healing. Olive oil is also a natural product that may contribute to wound healing owing to its antimicrobial and anti-inflammatory effects. The present study aimed to evaluate the effect of an Aloe vera-olive oil (AVO) combination cream on the healing process of chronic wounds. Method: In this randomised, double-blind, comparator-controlled, parallel-group trial, patients with chronic wounds were treated with either AVO cream or phenytoin cream as the standard treatment for a period of 30 days. Wound healing was evaluated using Bates-Jensen assessment tool and the severity of pain was assessed using a visual analogue scale (VAS). Results: After initial assessment, 60 patients with chronic wounds (41 with pressure ulcer, 13 with diabetic wounds and 6 with venous ulcers), were recruited and randomised into 2 groups of 30. After 30 days of treatment, significant improvements in the wound size, depth, and edges; necrotic tissue type and amount; exudate type and amount; colour of wound surroundings; and peripheral tissue oedema score were observed in the AVO cream group (p<0.001). The total score of wound healing showed significant improvement with both AVO (p<0.001) and phenytoin (p<0.01) creams, although AVO was more efficacious (p<0.001). Likewise, although both treatments reduced the initial VAS score, the efficacy of AVO was significantly greater (p<0.001). Conclusion: AVO cream significantly accelerates biological healing of chronic wounds and helps to reduce pain severity with a higher efficacy compared with phenytoin cream. Declaration of interest: The authors have no competing interest to declare.

Item Type: Article
Keywords: Aloe vera olive oil wound skin randomised controlled trial induced cutaneous complications blind clinical-trial virgin olive oil topical phenytoin nitric-oxide anal-fissure vera cream management efficacy gel Dermatology
Divisions:
Page Range: pp. 459-465
Journal or Publication Title: Journal of Wound Care
Journal Index: ISI
Volume: 24
Number: 10
Identification Number: https://doi.org/10.12968/jowc.2015.24.10.459
ISSN: 0969-0700
Depositing User: مهندس مهدی شریفی
URI: http://eprints.bmsu.ac.ir/id/eprint/5349

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