Repository of Research and Investigative Information

Repository of Research and Investigative Information

Baqiyatallah University of Medical Sciences

Immunological evaluation of OMV(PagL)+Bap((1-487aa)) and AbOmpA((8-346aa))+Bap((1-487aa)) as vaccine candidates against Acinetobacter baumannii sepsis infection

(2015) Immunological evaluation of OMV(PagL)+Bap((1-487aa)) and AbOmpA((8-346aa))+Bap((1-487aa)) as vaccine candidates against Acinetobacter baumannii sepsis infection. Molecular Immunology. pp. 552-558. ISSN 0161-5890

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Abstract

Acinetobacter baumannii is an important nosocomial pathogen that causes a high morbidity and mortality rate in infected patients with sepsis form. The surface exposed virulence proteins and serum resistance factors helping to dissemination of this bacterium to bloodstream are the most promising vaccine candidates against this microorganism. In this project we immunologically evaluated OMV(PagL) + BaP(1-487aa) and AbOmpA ((8-346aa)) + Bap((1-487aa)) as combination forms as well as Bap((1-487aa)), AbOmpA((8-346aa)) and OMV(PagL) singly, with addition of alum adjuvant as vaccine candidates. The titers of total IgG, IgG1 and IgG2c as well as concentration of IL-4 and IFN-gamma and survival rates were measured in a C57BL/6 murine model with disseminated sepsis. The ratio of IgG1/IgG2c and profile of IL-4/IFN-gamma in OMV ((PagL)) + Bap ((1-487aa)) formulation shows the humoral and cellular immune responses have been induced robustly and have created a full protection against A. baumannii ATCC 19606 and MDR AB-44 strains. We found that the two combination vaccine candidates were protective and induced both Th1 and Th2 responses. (C) 2015 Elsevier Ltd. All rights reserved.

Item Type: Article
Keywords: Acinetobacter baumannii vaccine candidates Outer membrane vesicle (OMV) Outer membrane protein of A. baumannii (AbOmpA) Biofilm-associated protein (Bap) biofilm-associated protein outer-membrane vesicles pathogenesis resistance cells mice Biochemistry & Molecular Biology Immunology
Divisions:
Page Range: pp. 552-558
Journal or Publication Title: Molecular Immunology
Journal Index: ISI
Volume: 67
Number: 2
Identification Number: https://doi.org/10.1016/j.molimm.2015.07.031
ISSN: 0161-5890
Depositing User: مهندس مهدی شریفی
URI: http://eprints.bmsu.ac.ir/id/eprint/5365

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