Repository of Research and Investigative Information

Repository of Research and Investigative Information

Baqiyatallah University of Medical Sciences

Noninvasive Ventilation in Mustard Airway Diseases

(2015) Noninvasive Ventilation in Mustard Airway Diseases. Respiratory Care. pp. 1324-1329. ISSN 0020-1324

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Abstract

BACKGROUND: Noninvasive ventilation (NIV) has been shown to improve numerous clinical measures in subjects with COPD, including gas exchange, exercise tolerance, dyspnea, hospitalizations, health-related quality of life (HRQOL), and functional status. Although useful for classical COPD, NIV has not been validated specifically as a treatment option for mustard airway disease. Our aim was to assess the efficacy of NIV in subjects with severe mustard airway disease. METHODS: This study was performed over the course of 12 months on 20 subjects with severe mustard airway disease (Global Initiative for Chronic Obstructive Lung Disease criteria). Subjects were selected from the pulmonary clinic of Baqiyatallah Hospital in Tehran, Iran. Body mass index, lung function, dyspnea, exercise tolerance, HRQOL, sleep quality, and hospitalization measures were assessed before and after NIV treatment. RESULTS: NIV improved HRQOL (P =.03) and sleep quality (P =.06) in very severe subjects and reduced hospitalizations (P =.003) and exacerbations (P =.01) in severe subjects. Chest imaging studies showed that these subjects had heterogeneous airway disease, the main finding of which was bronchiolitis obliterans. CONCLUSIONS: NIV can be used as an effective new palliative method in the treatment of mustard airway disorders. Subjects with very severe and severe disease benefitted differently from NIV. (c) 2015 Daedalus Enterprises

Item Type: Article
Keywords: noninvasive ventilation (NIV) sulfur mustard chronic obstructive respiratory disease (COPD) bronchiolitis obliterans positive-pressure ventilation obstructive pulmonary-disease sulfur mustard controlled-trial lung exposure copd capacity therapy sleep General & Internal Medicine Respiratory System
Divisions:
Page Range: pp. 1324-1329
Journal or Publication Title: Respiratory Care
Journal Index: ISI
Volume: 60
Number: 9
Identification Number: https://doi.org/10.4187/respcare.02900
ISSN: 0020-1324
Depositing User: مهندس مهدی شریفی
URI: http://eprints.bmsu.ac.ir/id/eprint/5382

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