(2015) In silico analyses of Wilms' tumor protein to designing a novel multi-epitope DNA vaccine against cancer. Journal of Theoretical Biology. pp. 66-78. ISSN 0022-5193
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Abstract
Predefined and pre-weighted objective criteria and essential role of Wilms' tumor wild type gene (WT1) for maintaining transformed features of cancer cells confirm the high potency of WT1 as a valuable cancer antigen. The antigen was at the top of the ranking among 75 representative cancer antigens. In the present study, an in silica approach was launched to characterized novel CTL epitopes and design a novel multi-epitope DNA vaccine to elicit a desirable immune response against cancers over expressing WT1. Forty-four novel epitopes were described. A multi-epitope construct was designed based on predicted epitopes which is 310 residues in length. The vaccine candidate designed here displays acceptable population coverage (> 65) in different ethnicities as well as high probability of eliciting WT1 antibodies which both are pertinent goals in the context of appropriate multi-epitope vaccines. Various in silico analyses indicate that final vaccine is a qualified immunotherapy candidate capable of eliciting both CD4+ and CD8+ T cell responses. (C) 2015 Elsevier Ltd. All rights reserved.
Item Type: | Article |
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Keywords: | WT1 Bioinformatics Immunotherapy T cell epitope t-cell responses peptide vaccine wt1 expression rna stability gene wt1 immunogenicity identification immunotherapy prediction leukemia Life Sciences & Biomedicine - Other Topics Mathematical & Computational Biology |
Divisions: | |
Page Range: | pp. 66-78 |
Journal or Publication Title: | Journal of Theoretical Biology |
Journal Index: | ISI |
Volume: | 379 |
Identification Number: | https://doi.org/10.1016/j.jtbi.2015.04.026 |
ISSN: | 0022-5193 |
Depositing User: | مهندس مهدی شریفی |
URI: | http://eprints.bmsu.ac.ir/id/eprint/5397 |
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