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Baqiyatallah University of Medical Sciences

Inactivation of the Nucl. Accumbens Core Exerts No Effect on Nicotine-Induced Conditioned Place Preference

(2015) Inactivation of the Nucl. Accumbens Core Exerts No Effect on Nicotine-Induced Conditioned Place Preference. Neurophysiology. pp. 295-301. ISSN 0090-2977

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Abstract

Effects of transient inhibition of the core part of the nucl. accumbens (NAcC) by lidocaine on nicotineinduced conditioned place preference in male Wistar rats were examined. Lidocaine (2) was injected into the NAcC of nicotine-conditioned animals before each nicotine i.p. injection. On the test day, behavior of the animals in a two-lcompartment apparatus was recorded during 10 min. Results revealed that i.p. injections of nicotine (1.0 or 1.5 mg/kg) induced place preference. Transient lidocaine-induced inhibition of one or both sides of the NAcC did not change place preference but changed the numbers of compartment crossings, rearings, and sniffings. Inhibition of the left part and both parts of the structure reduced sniffing and increased place preference; inhibition of the right part of the nucleus increased the intensity of this phenomena.

Item Type: Article
Keywords: nicotine conditioned place preference lidocaine core part of the nucl. accumbens shell part of the nucl. accumbens rat ventral tegmental area transient inactivation dopamine shell acquisition reward expression receptors asymmetry framework Neurosciences & Neurology Physiology
Divisions:
Page Range: pp. 295-301
Journal or Publication Title: Neurophysiology
Journal Index: ISI
Volume: 47
Number: 4
Identification Number: https://doi.org/10.1007/s11062-015-9536-8
ISSN: 0090-2977
Depositing User: مهندس مهدی شریفی
URI: http://eprints.bmsu.ac.ir/id/eprint/5402

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