Abstract

Three oxido-vanadium(V) complexes, VO2(L)NH(Et)(3) (1), VO(L)(PrO) (2) and VO(L)(BuO) (3), containing deprotonated form of the tridentate Schiff base ligand 1-(((5-chloro-2-oxidophenyl) imino)methyl)naphthalen-2-olate L2- have been synthesized and characterized using elemental analysis, molar conductivity, FTIR, H-1 NMR analysis, and electronic spectroscopy. The structures of the free H2L ligand and all the complexes were determined by single crystal X-ray diffraction. According to the spectroscopic and structural data, H2L exists in the solid state in a zwitterionic form. In all the complexes, the V(V) center is coordinated by the ONO donor set of the L2- ligand, one or two oxido groups and in the case of 2 and 3 by one alkoxide group (PrO- for 2 and BuO- for 3) in a distorted square pyramidal geometry. The anticancer activities of the title complexes have been also investigated against MCF-7 (breast cancer) cells and compared with that of VO(acac)(2). According to the obtained results, all the complexes possess higher anticancer activity than VO(acac)(2). (C) 2015 Elsevier Ltd. All rights reserved.