Repository of Research and Investigative Information

Repository of Research and Investigative Information

Baqiyatallah University of Medical Sciences

Fabrication of cancellous biomimetic chitosan-based nanocomposite scaffolds applying a combinational method for bone tissue engineering

(2015) Fabrication of cancellous biomimetic chitosan-based nanocomposite scaffolds applying a combinational method for bone tissue engineering. Journal of Biomedical Materials Research Part A. pp. 1882-1892. ISSN 1549-3296

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Abstract

The aim of this study was to mimic the specific structure of bone and fabricate a biomimetic nano-hydroxyapatite (HA)/chitosan (Cs)/gelatin scaffolds using combination of particle leaching and freeze drying methods eliminating mold effects. To achieve an optimum structure, scaffolds with different gelatin/Cs weight ratio were fabricated. Morphological characterization of scaffolds by scanning electron microscopy method showed highly interconnected porous structures similar to cancellous bone with mean pore size ranging from 140 to 190 m. Nano-HA crystals were dispersed homogeneously in the polymer matrix according to the energy-dispersive X-ray spectroscopy and transmission electron microscopy images. Fourier transform infrared and X-ray diffraction results disclosed that chemical interactions were formed between nano-HA, Cs, gelatin and crystallinity of each material decreased with blending. It was found that increasing the gelatin content significantly improved water uptake, degradation rate as well as attachment, infiltration and proliferation of Saos2 cells to the scaffolds. The presented results confirm that the designed biomimetic nano-HA /Cs/gelatin scaffolds can be used as promising substitutes for bone tissue engineering. (c) 2014 Wiley Periodicals, Inc. J Biomed Mater Res Part A: 103A: 1882-1892, 2015.

Item Type: Article
Keywords: bone tissue engineering nano-hydroxyapatite chitosan gelatin particle leaching freeze drying gelatin scaffolds composite scaffolds physical-properties porosity gelatin/chitosan differentiation growth size Engineering Materials Science
Divisions:
Page Range: pp. 1882-1892
Journal or Publication Title: Journal of Biomedical Materials Research Part A
Journal Index: ISI
Volume: 103
Number: 5
Identification Number: https://doi.org/10.1002/jbm.a.35320
ISSN: 1549-3296
Depositing User: مهندس مهدی شریفی
URI: http://eprints.bmsu.ac.ir/id/eprint/5485

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