Repository of Research and Investigative Information

Repository of Research and Investigative Information

Baqiyatallah University of Medical Sciences

Minimal inhibitory concentration of microorganisms causing surgical site infection in referral hospitals in North of Iran, 2011-2012

(2015) Minimal inhibitory concentration of microorganisms causing surgical site infection in referral hospitals in North of Iran, 2011-2012. Caspian Journal of Internal Medicine. pp. 34-39. ISSN 2008-6164

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Abstract

Background: A surgical site infection (SSI) is the most common nosocomial infection after surgery and is the third most common infection in hospitalized patients. The aim of this study was to asses minimum inhibitory concentration (MIC) of the causing agents of SSI and antimicrobial susceptibility patterns. Methods: This cross-sectional study was done in three referral hospitals in North of Iran during 2011-2012. The samples were taken one month after orthopedic, abdominal, cesarean section surgery and coronary artery bypass graft (CABG) in patients with scores compatible to SSIs criteria. The sample was sent for bacteriologic culture and MIC determination for positive cases by broth microdilution method. The data were collected and analyzed. Results: From 103 positive cases S. aureus, E. coli and coagulase negative staphylococci were the most common isolated agents as 29.12, 23.3 and 21.3, respectively. S. aureus was sensitive to vancomycin (70), amikacin (70) and teicoplanin (76.6) and cogulase negative staphylococci was sensitive to vancomycin (68.1) and teicoplanin (72.6) and E. coli to amikacin (95.83) and imipenem and meropenem (66.66). P. aeroginosa showed no sensitivity to cefepime and was sensitive to imipenem (93.75) and meropenem (81.25). Conclusion: The most important point is worrisome problem of the increased MIC of S. aureus to vancomycin that causes difficult use in the treatment of staphylococcal SSIs. In spite of resistance of micro-organisms to cephalosporins, gram negative organisms had low MIC to carbapenemes especially P. aeroginosa although the rate of its MIC is increasing.

Item Type: Article
Keywords: Minimal Inhibitory Concentration Surgical site infection Resistance Antibiotics resistant staphylococcus-aureus General & Internal Medicine
Divisions:
Page Range: pp. 34-39
Journal or Publication Title: Caspian Journal of Internal Medicine
Journal Index: ISI
Volume: 6
Number: 1
ISSN: 2008-6164
Depositing User: مهندس مهدی شریفی
URI: http://eprints.bmsu.ac.ir/id/eprint/5613

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