Repository of Research and Investigative Information

Repository of Research and Investigative Information

Baqiyatallah University of Medical Sciences

The Role of Hesperidin in Cell Signal Transduction Pathway for the Prevention or Treatment of Cancer

(2015) The Role of Hesperidin in Cell Signal Transduction Pathway for the Prevention or Treatment of Cancer. Current Medicinal Chemistry. pp. 3462-3471. ISSN 0929-8673

[img] Text
The Role of Hesperidin in Cell Signal Transduction Pathway for the Prevention or Treatment of Cancer.pdf

Download (1MB)

Official URL: http://apps.webofknowledge.com/InboundService.do?F...

Abstract

During past two decades, plant-derived bioactive compounds have been reported as novel therapeutic agents for prevention and/or mitigation of different human diseases such as cancer, inflammation, cardiovascular and neurodegenerative diseases. Hesperidin is known as one of the most common and bioactive constituents of Citrus (C) species which possesses multiple health-promotion effects. A plethora of scientific literature reported that hesperidin possesses in-vitro and in-vivo anticancer activities. In addition, there are numerous scientific evidences regarding the molecular mechanisms of anticancer activities of hesperidin and its aglycone, hesperetin. However, in this case, the number of comprehensive reviews on molecular mechanisms underlying the anticancer effects of hesperidin is sparse. Therefore, in this work we present a critical review of the available literature regarding the molecular mechanisms of the anticancer effects of hesperidin and its aglycone, hesperetin.

Item Type: Article
Keywords: Aglycone anticancer citrus flavonoid hesperetin hesperidin induced oxidative stress flavonoid hesperidin molecular-mechanisms antioxidant activity hesperetin activation apoptosis modulation quercetin flavanone Biochemistry & Molecular Biology Pharmacology & Pharmacy
Divisions:
Page Range: pp. 3462-3471
Journal or Publication Title: Current Medicinal Chemistry
Journal Index: ISI
Volume: 22
Number: 30
Identification Number: https://doi.org/10.2174/092986732230151019103810
ISSN: 0929-8673
Depositing User: مهندس مهدی شریفی
URI: http://eprints.bmsu.ac.ir/id/eprint/5617

Actions (login required)

View Item View Item