Repository of Research and Investigative Information

Repository of Research and Investigative Information

Baqiyatallah University of Medical Sciences

The Effect of Garcin (R) in Preventing AntiTB-Induced Hepatitis in Newly Diagnosed Tuberculosis Patients

(2014) The Effect of Garcin (R) in Preventing AntiTB-Induced Hepatitis in Newly Diagnosed Tuberculosis Patients. Iranian Journal of Pharmaceutical Research. pp. 169-175. ISSN 1735-0328

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Abstract

Adverse effects of antituberculosis agents such as hepatotoxicity may reduce treatment effectiveness, because they significantly contribute to nonadherence and eventually result in treatment failure, relapse or the emergence of drug resistance. Garlic is an ancient herbal substance, which its effectiveness on isoniazid and rifampicin-induced hepatic injury in animal models has been demonstrated (1). In the present study a randomized, double blind, placebo-controlled, parallel group clinical trial was designed to assess the effect(s) of garlic tablets (1000 mg daily) administered for two weeks orally. Fifty eight newly diagnosed, smear positive pulmonary tuberculosis patients, with age ranges between 18-65 years old, were randomly allocated into two groups. Each patient received either garlic or placebo tablets for the first two weeks of tuberculosis treatment. Of total 58 patients, 31 received garlic tablets while 27 received placebo. No significant difference was found between the two groups regarding age, sex, nationality, smoking, underlying diseases and opium usage. During 8 weeks of anti-TB (antituberculosis) treatment, 8 (13.0) patients developed drug-induced hepatotoxicity (DIH). Of them, 6 (75) occurred in the first two weeks of treatment. Fifty percent of the patients who developed DIH were in garlic group. Results indicated no significant difference between groups in developing DIH (p=1.000). We could not show a significant role in preventing DIH by 1000 mg daily garlic administration.

Item Type: Article
Keywords: Garlic Tuberculosis Drug-Induced hepatitis Clinical trial drug-induced hepatotoxicity garlic oil liver Pharmacology & Pharmacy
Divisions:
Page Range: pp. 169-175
Journal or Publication Title: Iranian Journal of Pharmaceutical Research
Journal Index: ISI
Volume: 13
ISSN: 1735-0328
Depositing User: مهندس مهدی شریفی
URI: http://eprints.bmsu.ac.ir/id/eprint/5649

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